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Synchronous ovarian and cervical squamous intraepithelial neoplasia: an analysis of HPV status

Synchronous ovarian and cervical squamous intraepithelial neoplasia: an analysis of HPV status
Synchronous ovarian and cervical squamous intraepithelial neoplasia: an analysis of HPV status
In contrast to the strong association between human papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN), the relationship between HPV and squamous epithelial lesions of the ovary is less clear. We report a case of synchronous ovarian and cervical squamous intraepithelial neoplasia. To investigate the possible association between HPV and squamous intraepithelial neoplasia/carcinomain situ(CIS) of the ovary, DNA was extracted from paraffin-embedded tissues including normal cervix, CIN, CIS from both ovaries, and an area of ovarian endometriosis. All samples were positive for HPV 16 E6 except for one of the two samples from the normal cervical squamous epithelium. These results support the hypothesis that HPV may be involved in the development of ovarian squamous intraepithelial neoplasia
0090-8258
428-431
Manolitsas, Tom P.
4cebc6ee-4430-4a4b-936f-4c08f4081018
Lanham, Stuart A.
28fdbbef-e3b6-4fdf-bd0f-4968eeb614d6
Hitchcock, Andrew
f34c34c4-fac4-42df-8dcd-61fa76409518
Watson, Richard H.
f799f96a-759f-4056-9231-78f57bb942bd
Manolitsas, Tom P.
4cebc6ee-4430-4a4b-936f-4c08f4081018
Lanham, Stuart A.
28fdbbef-e3b6-4fdf-bd0f-4968eeb614d6
Hitchcock, Andrew
f34c34c4-fac4-42df-8dcd-61fa76409518
Watson, Richard H.
f799f96a-759f-4056-9231-78f57bb942bd

Manolitsas, Tom P., Lanham, Stuart A., Hitchcock, Andrew and Watson, Richard H. (1998) Synchronous ovarian and cervical squamous intraepithelial neoplasia: an analysis of HPV status Gynecologic Oncology, 70, (3), pp. 428-431. (doi:10.1006/gyno.1998.5058). (PMID:9790801).

Record type: Article

Abstract

In contrast to the strong association between human papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN), the relationship between HPV and squamous epithelial lesions of the ovary is less clear. We report a case of synchronous ovarian and cervical squamous intraepithelial neoplasia. To investigate the possible association between HPV and squamous intraepithelial neoplasia/carcinomain situ(CIS) of the ovary, DNA was extracted from paraffin-embedded tissues including normal cervix, CIN, CIS from both ovaries, and an area of ovarian endometriosis. All samples were positive for HPV 16 E6 except for one of the two samples from the normal cervical squamous epithelium. These results support the hypothesis that HPV may be involved in the development of ovarian squamous intraepithelial neoplasia

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Published date: September 1998
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 348225
URI: http://eprints.soton.ac.uk/id/eprint/348225
ISSN: 0090-8258
PURE UUID: 787846a1-f70e-4acb-862d-aff56012eb22
ORCID for Stuart A. Lanham: ORCID iD orcid.org/0000-0002-4516-264X

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Date deposited: 01 Mar 2013 14:53
Last modified: 18 Jul 2017 04:53

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Contributors

Author: Tom P. Manolitsas
Author: Stuart A. Lanham ORCID iD
Author: Andrew Hitchcock
Author: Richard H. Watson

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