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Weight in infancy and adult calcium absorption as determinants of bone mineral density in adult men: the Hertfordshire cohort study

Weight in infancy and adult calcium absorption as determinants of bone mineral density in adult men: the Hertfordshire cohort study
Weight in infancy and adult calcium absorption as determinants of bone mineral density in adult men: the Hertfordshire cohort study
Adult bone mass is modified by early life environmental influences, but the mechanism of this association is uncertain. Data support an inverse relationship between intestinal calcium absorption (?Ca) and birth weight in women. However, little is known regarding determinants in men. This study examines the association between weight in infancy and adult ?Ca in healthy men and whether this could be a mechanism by which the early life environment may influence bone mass. Men were recruited from the MRC Hertfordshire Cohort Study, for whom detailed early life records were available. Areal bone mineral density (aBMD) was measured using a Hologic QDR 4500 at the femoral neck (FN) and lumbar spine. We randomly selected 123 men stratified by birth weight and assessed ?Ca using the stable strontium absorption test. The mean age was 63.6 (SD 2.5) years. ?Ca was not associated with birth weight or weight at 1 year. FN aBMD was associated with both weight at 1 year (r = 0.20, p = 0.03) and ?Ca (r = 0.20, p = 0.03). Both of these associations remained statistically significant in a mutually adjusted, multivariable model but would account for only ~4 % variance in BMD. We demonstrated a positive association between weight at 1 year and aBMD and between ?Ca and FN BMD, but no association was found between birth weight and ?Ca. This suggests that in men, although ?Ca is a contributing factor in FN bone density, it is not the main mechanism whereby the early environment modifies adult BMD.

0171-967X
416-422
Patel, M.B.
9936f9c0-6f87-49ef-94b0-970b26fff222
Makepeace, A.E.
0244db40-c1ec-4802-bb8e-32847622315e
Jameson, K.A.
d5fb142d-06af-456e-9016-17497f94e9f2
Masterton, L.M.
0d12e4ae-2dd4-4b1e-b89d-da6d2c19625e
Holt, R.I.
d54202e1-fcf6-4a17-a320-9f32d7024393
Swaminathan, R.
0fe42e66-d2fc-48c9-8acb-c4e5ab0b9c97
Javaid, M.K.
51d3310b-032e-4c15-83ac-b878bce090f3
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Arden, N.K.
23af958d-835c-4d79-be54-4bbe4c68077f
Patel, M.B.
9936f9c0-6f87-49ef-94b0-970b26fff222
Makepeace, A.E.
0244db40-c1ec-4802-bb8e-32847622315e
Jameson, K.A.
d5fb142d-06af-456e-9016-17497f94e9f2
Masterton, L.M.
0d12e4ae-2dd4-4b1e-b89d-da6d2c19625e
Holt, R.I.
d54202e1-fcf6-4a17-a320-9f32d7024393
Swaminathan, R.
0fe42e66-d2fc-48c9-8acb-c4e5ab0b9c97
Javaid, M.K.
51d3310b-032e-4c15-83ac-b878bce090f3
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Arden, N.K.
23af958d-835c-4d79-be54-4bbe4c68077f

Patel, M.B., Makepeace, A.E., Jameson, K.A., Masterton, L.M., Holt, R.I., Swaminathan, R., Javaid, M.K., Cooper, C. and Arden, N.K. (2012) Weight in infancy and adult calcium absorption as determinants of bone mineral density in adult men: the Hertfordshire cohort study. Calcified Tissue International, 91 (6), 416-422. (doi:10.1007/s00223-012-9648-8.). (PMID:23010962)

Record type: Article

Abstract

Adult bone mass is modified by early life environmental influences, but the mechanism of this association is uncertain. Data support an inverse relationship between intestinal calcium absorption (?Ca) and birth weight in women. However, little is known regarding determinants in men. This study examines the association between weight in infancy and adult ?Ca in healthy men and whether this could be a mechanism by which the early life environment may influence bone mass. Men were recruited from the MRC Hertfordshire Cohort Study, for whom detailed early life records were available. Areal bone mineral density (aBMD) was measured using a Hologic QDR 4500 at the femoral neck (FN) and lumbar spine. We randomly selected 123 men stratified by birth weight and assessed ?Ca using the stable strontium absorption test. The mean age was 63.6 (SD 2.5) years. ?Ca was not associated with birth weight or weight at 1 year. FN aBMD was associated with both weight at 1 year (r = 0.20, p = 0.03) and ?Ca (r = 0.20, p = 0.03). Both of these associations remained statistically significant in a mutually adjusted, multivariable model but would account for only ~4 % variance in BMD. We demonstrated a positive association between weight at 1 year and aBMD and between ?Ca and FN BMD, but no association was found between birth weight and ?Ca. This suggests that in men, although ?Ca is a contributing factor in FN bone density, it is not the main mechanism whereby the early environment modifies adult BMD.

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Published date: December 2012
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 348280
URI: http://eprints.soton.ac.uk/id/eprint/348280
ISSN: 0171-967X
PURE UUID: 36a04e01-ee51-4b12-89f6-fe66b5e2492a
ORCID for R.I. Holt: ORCID iD orcid.org/0000-0001-8911-6744
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 11 Feb 2013 16:40
Last modified: 18 Mar 2024 02:53

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Contributors

Author: M.B. Patel
Author: A.E. Makepeace
Author: K.A. Jameson
Author: L.M. Masterton
Author: R.I. Holt ORCID iD
Author: R. Swaminathan
Author: M.K. Javaid
Author: C. Cooper ORCID iD
Author: N.K. Arden

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