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Microperimetric changes in neovascular age-related macular degeneration treated with ranibizumab

Microperimetric changes in neovascular age-related macular degeneration treated with ranibizumab
Microperimetric changes in neovascular age-related macular degeneration treated with ranibizumab
PURPOSE: To assess the value of microperimetry in eyes with neovascular age-related macular degeneration previously treated with ranibizumab and now in the maintenance phase of therapy.

METHODS: A total of 21 eyes (14 patients) were included. Microperimetry was performed using the Macular Integrity Assessment Device on at least three occasions for each eye. Intravitreal ranibizumab was administered if visual acuity (VA) or optical coherence tomography (OCT) showed signs of active disease.

RESULTS: Five eyes showed no change in VA or OCT findings, and required no intravitreal injections. In these eyes, mean threshold sensitivity (TS) decreased by 13% (paired t-test, P=0.05) during the study period, but fixation stability (FS) was unchanged. In all, 16 eyes showed signs of disease activity, and therefore required ranibizumab injections during the study. In these eyes, VA, central retinal thickness (CRT), FS, and TS remained unchanged during follow-up. Peak TS was noted when CRT was 210 ?m; above or below 210 ?m, there was a gradual reduction in TS.

CONCLUSION: This study has provided novel information on the relationship between macular sensitivity, CRT, and VA in the maintenance phase of ranibizumab therapy. Patients with stable VA and CRT may still have deteriorating retinal sensitivity. This is usually a late manifestation and may indicate subclinical CNV activity.

0950-222X
678-683
Alexander, P.
e43546a3-01a5-46fd-9dd7-4d157f5623cd
Mushtaq, F.
03115150-2917-44aa-b692-1496dbe0f7b2
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Amoaku, W.
0138eb63-d27c-4a56-b51a-bcab50efef06
Alexander, P.
e43546a3-01a5-46fd-9dd7-4d157f5623cd
Mushtaq, F.
03115150-2917-44aa-b692-1496dbe0f7b2
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Amoaku, W.
0138eb63-d27c-4a56-b51a-bcab50efef06

Alexander, P., Mushtaq, F., Osmond, C. and Amoaku, W. (2012) Microperimetric changes in neovascular age-related macular degeneration treated with ranibizumab. Eye, 26 (5), 678-683. (PMID:22322998)

Record type: Article

Abstract

PURPOSE: To assess the value of microperimetry in eyes with neovascular age-related macular degeneration previously treated with ranibizumab and now in the maintenance phase of therapy.

METHODS: A total of 21 eyes (14 patients) were included. Microperimetry was performed using the Macular Integrity Assessment Device on at least three occasions for each eye. Intravitreal ranibizumab was administered if visual acuity (VA) or optical coherence tomography (OCT) showed signs of active disease.

RESULTS: Five eyes showed no change in VA or OCT findings, and required no intravitreal injections. In these eyes, mean threshold sensitivity (TS) decreased by 13% (paired t-test, P=0.05) during the study period, but fixation stability (FS) was unchanged. In all, 16 eyes showed signs of disease activity, and therefore required ranibizumab injections during the study. In these eyes, VA, central retinal thickness (CRT), FS, and TS remained unchanged during follow-up. Peak TS was noted when CRT was 210 ?m; above or below 210 ?m, there was a gradual reduction in TS.

CONCLUSION: This study has provided novel information on the relationship between macular sensitivity, CRT, and VA in the maintenance phase of ranibizumab therapy. Patients with stable VA and CRT may still have deteriorating retinal sensitivity. This is usually a late manifestation and may indicate subclinical CNV activity.

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More information

Published date: May 2012
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 348298
URI: https://eprints.soton.ac.uk/id/eprint/348298
ISSN: 0950-222X
PURE UUID: 9063d953-c590-4f97-bd0c-59850d936eeb
ORCID for C. Osmond: ORCID iD orcid.org/0000-0002-9054-4655

Catalogue record

Date deposited: 12 Feb 2013 10:28
Last modified: 06 Jun 2018 13:04

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