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Population differences in brain morphology and microstructure among Chinese, Malay, and Indian neonates

Population differences in brain morphology and microstructure among Chinese, Malay, and Indian neonates
Population differences in brain morphology and microstructure among Chinese, Malay, and Indian neonates
We studied a sample of 75 Chinese, 73 Malay, and 29 Indian healthy neonates taking part in a cohort study to examine potential differences in neonatal brain morphology and white matter microstructure as a function of ethnicity using both structural T2-weighted magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). We first examined the differences in global size and morphology of the brain among the three groups. We then constructed the T2-weighted MRI and DTI atlases and employed voxel-based analysis to investigate ethnic differences in morphological shape of the brain from the T2-weighted MRI, and white matter microstructure measured by fractional anisotropy derived from DTI. Compared with Malay neonates, the brains of Indian neonates’ tended to be more elongated in anterior and posterior axis relative to the superior-inferior axis of the brain even though the total brain volume was similar among the three groups. Although most anatomical regions of the brain were similar among Chinese, Malay, and Indian neonates, there were anatomical variations in the spinal-cerebellar and cortical-striatal-thalamic neural circuits among the three populations. The population-related brain regions highlighted in our study are key anatomical substrates associated with sensorimotor functions.
1932-6203
e47816
Bai, J.
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Abdul-Rahman, M.F.
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Rifkin-Graboi, A.
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Chong, Y.S.
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Kwek, K.
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Saw, S.M.
0684517e-f27e-49f0-98c3-7630e8fd1bbd
Godfrey, K.M.
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Gluckman, P.D.
492295c0-ef71-4871-ad5a-771c98e1059a
Fortier, M.V.
3567d96b-8db6-41be-88fd-45af16ebb7da
Meaney, M.J.
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Qiu, A.
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Bai, J.
823a05e0-144e-4dad-97f3-f8d942141e6c
Abdul-Rahman, M.F.
8b610fd6-34de-4e18-b6dd-d3ca6c2cf3f4
Rifkin-Graboi, A.
1076b6c7-308c-4434-a5c0-eaa08ffa563c
Chong, Y.S.
b50c99c9-4d83-46c5-a1c7-23f9a553ab8a
Kwek, K.
1a9b6c6e-a5e9-40a2-9bfe-44c2cea62a98
Saw, S.M.
0684517e-f27e-49f0-98c3-7630e8fd1bbd
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Gluckman, P.D.
492295c0-ef71-4871-ad5a-771c98e1059a
Fortier, M.V.
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Meaney, M.J.
cb875853-8497-4382-9aff-739714aa49f9
Qiu, A.
90e8e2a4-0a2d-4004-991e-70c6fe3f6d71

Bai, J., Abdul-Rahman, M.F., Rifkin-Graboi, A., Chong, Y.S., Kwek, K., Saw, S.M., Godfrey, K.M., Gluckman, P.D., Fortier, M.V., Meaney, M.J. and Qiu, A. (2012) Population differences in brain morphology and microstructure among Chinese, Malay, and Indian neonates. PLoS ONE, 7 (10), e47816. (doi:10.1371/journal.pone.0047816). (PMID:23112850)

Record type: Article

Abstract

We studied a sample of 75 Chinese, 73 Malay, and 29 Indian healthy neonates taking part in a cohort study to examine potential differences in neonatal brain morphology and white matter microstructure as a function of ethnicity using both structural T2-weighted magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). We first examined the differences in global size and morphology of the brain among the three groups. We then constructed the T2-weighted MRI and DTI atlases and employed voxel-based analysis to investigate ethnic differences in morphological shape of the brain from the T2-weighted MRI, and white matter microstructure measured by fractional anisotropy derived from DTI. Compared with Malay neonates, the brains of Indian neonates’ tended to be more elongated in anterior and posterior axis relative to the superior-inferior axis of the brain even though the total brain volume was similar among the three groups. Although most anatomical regions of the brain were similar among Chinese, Malay, and Indian neonates, there were anatomical variations in the spinal-cerebellar and cortical-striatal-thalamic neural circuits among the three populations. The population-related brain regions highlighted in our study are key anatomical substrates associated with sensorimotor functions.

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Published date: 24 October 2012
Organisations: Faculty of Medicine

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Local EPrints ID: 348311
URI: https://eprints.soton.ac.uk/id/eprint/348311
ISSN: 1932-6203
PURE UUID: c78fda71-7981-4291-9c78-e585cdaba6b8
ORCID for K.M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

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Date deposited: 12 Feb 2013 14:10
Last modified: 05 Nov 2019 02:05

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Contributors

Author: J. Bai
Author: M.F. Abdul-Rahman
Author: A. Rifkin-Graboi
Author: Y.S. Chong
Author: K. Kwek
Author: S.M. Saw
Author: K.M. Godfrey ORCID iD
Author: P.D. Gluckman
Author: M.V. Fortier
Author: M.J. Meaney
Author: A. Qiu

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