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Postpartum depressive symptoms: the B-vitamin link

Postpartum depressive symptoms: the B-vitamin link
Postpartum depressive symptoms: the B-vitamin link
Objective This study examined longitudinal relationships between maternal red-cell folate status and dietary intakes of vitamins B(6), B(12) and folate before and during pregnancy and subsequent postpartum depressive symptoms.Study design and setting Within a cohort study of women aged 20-34 years (the Southampton Women's Survey) dietary data were obtained before pregnancy and at 11 and 34 weeks' gestation. Red-cell folate was measured before pregnancy and at 11 weeks' gestation. We derived relative risks of postpartum depressive symptoms using an Edinburgh Postnatal Depression Scale (EPDS) score of ? 13 administered from 6 months to 1 year postpartum.Results No significant differences were found between those with postpartum depressive symptoms (n = 905) and those without (n = 1951) in relation to red-cell folate concentration or dietary intake of folate, vitamin B(12) and vitamin B(6), before or during pregnancy. A prior history of mental illness (relative risk (RR) 1.83; 95% confidence interval (CI) 1.53-2.19) was associated with postpartum depressive symptoms, and women who breastfed until 6 months were less likely to experience postpartum depressive symptoms (RR 0.68; 95% CI 0.55-0.84).Conclusion This study suggests that folate status and dietary folate, B(6) and B(12) intakes before and during pregnancy are not associated with postpartum depressive symptoms. A history of mental illness, however, was a strong risk factor.
1756-834X
5-13
Blunden, C.H.
baf7cf48-a3be-4e65-9830-dc0f9cc69c46
Inskip, H.M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Robinson, S.M.
ba591c98-4380-456a-be8a-c452f992b69b
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Kendrick, T.R.
c697a72c-c698-469d-8ac2-f00df40583e5
Blunden, C.H.
baf7cf48-a3be-4e65-9830-dc0f9cc69c46
Inskip, H.M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Robinson, S.M.
ba591c98-4380-456a-be8a-c452f992b69b
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Kendrick, T.R.
c697a72c-c698-469d-8ac2-f00df40583e5

Blunden, C.H., Inskip, H.M., Robinson, S.M., Cooper, C., Godfrey, K.M. and Kendrick, T.R. (2012) Postpartum depressive symptoms: the B-vitamin link. Mental Health in Family Medicine, 9 (1), 5-13. (PMID:23277793)

Record type: Article

Abstract

Objective This study examined longitudinal relationships between maternal red-cell folate status and dietary intakes of vitamins B(6), B(12) and folate before and during pregnancy and subsequent postpartum depressive symptoms.Study design and setting Within a cohort study of women aged 20-34 years (the Southampton Women's Survey) dietary data were obtained before pregnancy and at 11 and 34 weeks' gestation. Red-cell folate was measured before pregnancy and at 11 weeks' gestation. We derived relative risks of postpartum depressive symptoms using an Edinburgh Postnatal Depression Scale (EPDS) score of ? 13 administered from 6 months to 1 year postpartum.Results No significant differences were found between those with postpartum depressive symptoms (n = 905) and those without (n = 1951) in relation to red-cell folate concentration or dietary intake of folate, vitamin B(12) and vitamin B(6), before or during pregnancy. A prior history of mental illness (relative risk (RR) 1.83; 95% confidence interval (CI) 1.53-2.19) was associated with postpartum depressive symptoms, and women who breastfed until 6 months were less likely to experience postpartum depressive symptoms (RR 0.68; 95% CI 0.55-0.84).Conclusion This study suggests that folate status and dietary folate, B(6) and B(12) intakes before and during pregnancy are not associated with postpartum depressive symptoms. A history of mental illness, however, was a strong risk factor.

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Published date: January 2012
Organisations: Faculty of Health Sciences

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Local EPrints ID: 348322
URI: https://eprints.soton.ac.uk/id/eprint/348322
ISSN: 1756-834X
PURE UUID: 281a7bbd-9052-4df8-9128-5e60bc927df6
ORCID for H.M. Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for S.M. Robinson: ORCID iD orcid.org/0000-0003-1766-7269
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for K.M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618
ORCID for T.R. Kendrick: ORCID iD orcid.org/0000-0003-1618-9381

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Date deposited: 12 Feb 2013 13:55
Last modified: 20 Jul 2019 01:27

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Contributors

Author: C.H. Blunden
Author: H.M. Inskip ORCID iD
Author: S.M. Robinson ORCID iD
Author: C. Cooper ORCID iD
Author: K.M. Godfrey ORCID iD
Author: T.R. Kendrick ORCID iD

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