Symptoms of anxiety or depression and risk of fracture in older people: the Hertfordshire Cohort Study
Symptoms of anxiety or depression and risk of fracture in older people: the Hertfordshire Cohort Study
Summary
The aim of this study was to examine the prospective association between symptoms of anxiety and depression and risk of fracture in older people. Results showed that men, but not women, with probable anxiety at baseline had an increased risk of fracture.
Introduction
The use of psychotropic drugs has been linked with an increased risk of fracture in older people, but there are indications that the conditions for which these drugs were prescribed may themselves influence fracture risk. The aim of this study was to investigate the relation between symptoms of anxiety and depression and risk of fracture in older people. The study design is a prospective cohort study.
Methods
One thousand eighty-seven men and 1,050 women aged 59–73 years completed the Hospital Anxiety and Depression Scale (HADS). Data on incident fracture during an average follow-up period of 5.6 years were collected through interview and a postal questionnaire.
Results
Compared to men with no or few symptoms of anxiety (score ?7 on the HADS anxiety subscale), men with probable anxiety (score ?11) had an increased risk of fracture: After adjustment for age and potential confounding factors, the odds ratio (OR) (95 % confidence interval) was 4.03 (1.55, 10.5). There were no associations between levels of anxiety and fracture risk in women. Few men or women had probable depression at baseline (score ?11 on the HADS depression subscale). Amongst men with possible depression (score 8–10), there was an increased risk of fracture that was of borderline significance: multivariate-adjusted OR 3.57 (0.99, 12.9). There was no association between possible depression and fracture risk in women.
Conclusions
High levels of anxiety in older men may increase their risk of fracture. Future research needs to replicate this finding in other populations and investigate the underlying mechanisms.
59-65
Gale, C.R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Edwards, M.
b81ff294-1d16-4a1b-af14-9374c5989d4c
Sayer, A.A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
December 2012
Gale, C.R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Edwards, M.
b81ff294-1d16-4a1b-af14-9374c5989d4c
Sayer, A.A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Gale, C.R., Dennison, E.M., Edwards, M., Sayer, A.A. and Cooper, C.
(2012)
Symptoms of anxiety or depression and risk of fracture in older people: the Hertfordshire Cohort Study.
Archives of Osteoporosis, 7 (1-2), .
(doi:10.1007/s11657-012-0080-5).
(PMID:23225282)
Abstract
Summary
The aim of this study was to examine the prospective association between symptoms of anxiety and depression and risk of fracture in older people. Results showed that men, but not women, with probable anxiety at baseline had an increased risk of fracture.
Introduction
The use of psychotropic drugs has been linked with an increased risk of fracture in older people, but there are indications that the conditions for which these drugs were prescribed may themselves influence fracture risk. The aim of this study was to investigate the relation between symptoms of anxiety and depression and risk of fracture in older people. The study design is a prospective cohort study.
Methods
One thousand eighty-seven men and 1,050 women aged 59–73 years completed the Hospital Anxiety and Depression Scale (HADS). Data on incident fracture during an average follow-up period of 5.6 years were collected through interview and a postal questionnaire.
Results
Compared to men with no or few symptoms of anxiety (score ?7 on the HADS anxiety subscale), men with probable anxiety (score ?11) had an increased risk of fracture: After adjustment for age and potential confounding factors, the odds ratio (OR) (95 % confidence interval) was 4.03 (1.55, 10.5). There were no associations between levels of anxiety and fracture risk in women. Few men or women had probable depression at baseline (score ?11 on the HADS depression subscale). Amongst men with possible depression (score 8–10), there was an increased risk of fracture that was of borderline significance: multivariate-adjusted OR 3.57 (0.99, 12.9). There was no association between possible depression and fracture risk in women.
Conclusions
High levels of anxiety in older men may increase their risk of fracture. Future research needs to replicate this finding in other populations and investigate the underlying mechanisms.
This record has no associated files available for download.
More information
e-pub ahead of print date: 12 April 2012
Published date: December 2012
Organisations:
Faculty of Health Sciences
Identifiers
Local EPrints ID: 348345
URI: http://eprints.soton.ac.uk/id/eprint/348345
ISSN: 1862-3522
PURE UUID: aaee4717-8ce7-4258-9f5b-8982eec410af
Catalogue record
Date deposited: 12 Feb 2013 14:16
Last modified: 18 Mar 2024 02:45
Export record
Altmetrics
Contributors
Author:
M. Edwards
Author:
A.A. Sayer
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
