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The initial phase of fracture healing is specifically sensitive to mechanical conditions

The initial phase of fracture healing is specifically sensitive to mechanical conditions
The initial phase of fracture healing is specifically sensitive to mechanical conditions
Interfragmentary movements affect the quality and quantity of callus formation. The mounting plane of monolateral external fixators may give direction to those movements. Therefore, the aim of this study was to determine the influence of the fixator mounting plane on the process of fracture healing.Identically configured fixators were mounted either medially or anteromedially on the tibiae of sheep. Interfragmentary movements and ground reaction forces were evaluated in vivo during a nine week period. Histomorphological and biomechanical parameters described the bone healing processes.Changing only the mounting plane led to a modification of interfragmentary movements in the initial healing phase. The difference in interfragmentary movements between the groups was only significant during the first post-operative period. However, these initial differences in mechanical conditions influenced callus tissue formation significantly. The group with the anteromedially mounted fixator, initially showing significantly more interfragmentary movements, ended up with a significantly smaller callus diameter and a significantly higher callus stiffness as a result of advanced fracture healing. This demonstrates that the initial phase of healing is sensitive to mechanical conditions and influences the course of healing. Therefore, initial mechanical stability of an osteosynthesis should be considered an important factor in clinical fracture treatment.
fracture healing, external fixator, interfragmentary movements
0736-0266
662-669
Klein, Petra
22480ad7-311e-42d6-aca1-c8364ea2a082
Schell, Hanna
8fb2a511-e2bb-4193-8cd3-19387eb344ec
Streitparth, Florian
39e430c9-862e-496a-b934-5c46a16d71c8
Heller, Markus
3da19d2a-f34d-4ff1-8a34-9b5a7e695829
Kassi, Jean-Pierre
ac35a5d6-9253-43f3-bfca-5587f3fde3ed
Kandziora, Frank
e11d6dfc-1dce-4cd2-bb6d-1105d578f2ea
Bragulla, Hermann
f66cab78-c040-4ddf-9b7b-846abff616ee
Haas, Norbert P.
94a96d7c-e62e-4f46-b2ff-35bb52dc5bd4
Duda, Georg N.
ac4e207b-3e2e-4c84-a6c4-cb67531f890b
Klein, Petra
22480ad7-311e-42d6-aca1-c8364ea2a082
Schell, Hanna
8fb2a511-e2bb-4193-8cd3-19387eb344ec
Streitparth, Florian
39e430c9-862e-496a-b934-5c46a16d71c8
Heller, Markus
3da19d2a-f34d-4ff1-8a34-9b5a7e695829
Kassi, Jean-Pierre
ac35a5d6-9253-43f3-bfca-5587f3fde3ed
Kandziora, Frank
e11d6dfc-1dce-4cd2-bb6d-1105d578f2ea
Bragulla, Hermann
f66cab78-c040-4ddf-9b7b-846abff616ee
Haas, Norbert P.
94a96d7c-e62e-4f46-b2ff-35bb52dc5bd4
Duda, Georg N.
ac4e207b-3e2e-4c84-a6c4-cb67531f890b

Klein, Petra, Schell, Hanna, Streitparth, Florian, Heller, Markus, Kassi, Jean-Pierre, Kandziora, Frank, Bragulla, Hermann, Haas, Norbert P. and Duda, Georg N. (2003) The initial phase of fracture healing is specifically sensitive to mechanical conditions. Journal of Orthopaedic Research, 21 (4), 662-669. (doi:10.1016/S0736-0266(02)00259-0).

Record type: Article

Abstract

Interfragmentary movements affect the quality and quantity of callus formation. The mounting plane of monolateral external fixators may give direction to those movements. Therefore, the aim of this study was to determine the influence of the fixator mounting plane on the process of fracture healing.Identically configured fixators were mounted either medially or anteromedially on the tibiae of sheep. Interfragmentary movements and ground reaction forces were evaluated in vivo during a nine week period. Histomorphological and biomechanical parameters described the bone healing processes.Changing only the mounting plane led to a modification of interfragmentary movements in the initial healing phase. The difference in interfragmentary movements between the groups was only significant during the first post-operative period. However, these initial differences in mechanical conditions influenced callus tissue formation significantly. The group with the anteromedially mounted fixator, initially showing significantly more interfragmentary movements, ended up with a significantly smaller callus diameter and a significantly higher callus stiffness as a result of advanced fracture healing. This demonstrates that the initial phase of healing is sensitive to mechanical conditions and influences the course of healing. Therefore, initial mechanical stability of an osteosynthesis should be considered an important factor in clinical fracture treatment.

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More information

Published date: July 2003
Keywords: fracture healing, external fixator, interfragmentary movements
Organisations: Bioengineering Group

Identifiers

Local EPrints ID: 348499
URI: http://eprints.soton.ac.uk/id/eprint/348499
ISSN: 0736-0266
PURE UUID: 14c06e73-3785-42e6-8a8c-28030ce105a1
ORCID for Markus Heller: ORCID iD orcid.org/0000-0002-7879-1135

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Date deposited: 26 Feb 2013 12:38
Last modified: 03 Dec 2019 01:38

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Contributors

Author: Petra Klein
Author: Hanna Schell
Author: Florian Streitparth
Author: Markus Heller ORCID iD
Author: Jean-Pierre Kassi
Author: Frank Kandziora
Author: Hermann Bragulla
Author: Norbert P. Haas
Author: Georg N. Duda

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