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First one-pot organocatalytic synthesis of α-methylene-γ-lactones

First one-pot organocatalytic synthesis of α-methylene-γ-lactones
First one-pot organocatalytic synthesis of α-methylene-γ-lactones
All in one pot: an organocatalytic highly enantioselective synthesis of α-methylene-γ-lactones has been reported. The reaction between protected 2-hydroxymalonates and MBH carbonates is simply catalysed by chiral Lewis bases affording after acid treatment the corresponding lactones in excellent yields and enantioselectivities.
1359-7345
1184-1186
Companyó, Xavier
446791db-6e0a-40f9-9f20-3a8e8af9803c
Mazzanti, Andrea
1e31a7a1-e163-4bd4-9e72-42bc64f60277
Moyano, Albert
07f92405-40f4-4fc4-97b3-9bd5c9c14baa
Janecka, Anna
880b9e5a-5050-48d7-8499-877e4bd78473
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Companyó, Xavier
446791db-6e0a-40f9-9f20-3a8e8af9803c
Mazzanti, Andrea
1e31a7a1-e163-4bd4-9e72-42bc64f60277
Moyano, Albert
07f92405-40f4-4fc4-97b3-9bd5c9c14baa
Janecka, Anna
880b9e5a-5050-48d7-8499-877e4bd78473
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441

Companyó, Xavier, Mazzanti, Andrea, Moyano, Albert, Janecka, Anna and Rios, Ramon (2013) First one-pot organocatalytic synthesis of α-methylene-γ-lactones. Chemical Communications, 49 (12), 1184-1186. (doi:10.1039/C2CC38659C).

Record type: Article

Abstract

All in one pot: an organocatalytic highly enantioselective synthesis of α-methylene-γ-lactones has been reported. The reaction between protected 2-hydroxymalonates and MBH carbonates is simply catalysed by chiral Lewis bases affording after acid treatment the corresponding lactones in excellent yields and enantioselectivities.

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More information

Accepted/In Press date: 18 December 2012
e-pub ahead of print date: 19 December 2012
Published date: 2013
Related URLs:
Organisations: Organic Chemistry: Synthesis, Catalysis and Flow, Chemistry, Faculty of Natural and Environmental Sciences
Learn more about Chemistry research

Identifiers

Local EPrints ID: 348580
URI: http://eprints.soton.ac.uk/id/eprint/348580
DOI: doi:10.1039/C2CC38659C
ISSN: 1359-7345
PURE UUID: 6977619b-8cae-4126-ae0f-fb8b74f8373f
ORCID for Ramon Rios: ORCID iD orcid.org/0000-0002-3843-8521

Catalogue record

Date deposited: 14 Feb 2013 13:54
Last modified: 14 Mar 2024 13:02

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Contributors

Author: Xavier Companyó
Author: Andrea Mazzanti
Author: Albert Moyano
Author: Anna Janecka
Author: Ramon Rios ORCID iD

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