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Discovery and evaluation of a functional ternary polymer blend for bone repair: translation from a microarry to a clinical model

Discovery and evaluation of a functional ternary polymer blend for bone repair: translation from a microarry to a clinical model
Discovery and evaluation of a functional ternary polymer blend for bone repair: translation from a microarry to a clinical model
Skeletal tissue regeneration is often required following trauma, where substantial bone or cartilage loss may be encountered and is a significant driver for the development of biomaterials with a defined 3D structural network. Solvent blending is a process that avoids complications associated with conventional thermal or mechanical polymer blending or synthesis, opening up large areas of chemical and physical space, while potentially simplifying regulatory pathways towards in vivo application. Here ternary mixtures of natural and synthetic polymers were solvent blended and evaluated as potential bone tissue engineering matrices for osteoregeneration by the assessment of growth and differentiation of STRO-1+ skeletal stem cells. Several of the blend materials were found to be excellent supports for human bone marrow-derived STRO-1+ skeletal cells and fetal skeletal cells, with the optimized blend exhibiting in vivo osteogenic potential, suggesting that these polymer blends could act as suitable matrices for bioengineering of hard tissues.
biomaterials, skeletal tissue, scaffold, skeletal stem, cells, tissue engineering, polymer blends
1616-301X
1-13
Khan, Ferdous
e42bd53d-7669-4a7e-bb33-f17b70660c2b
Smith, James O.
027f2a5a-1966-4077-97a7-f70d2e6b06b2
Kanczler, Janos M.
eb8db9ff-a038-475f-9030-48eef2b0559c
Tare, Rahul S.
587c9db4-e409-4e7c-a02a-677547ab724a
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Khan, Ferdous
e42bd53d-7669-4a7e-bb33-f17b70660c2b
Smith, James O.
027f2a5a-1966-4077-97a7-f70d2e6b06b2
Kanczler, Janos M.
eb8db9ff-a038-475f-9030-48eef2b0559c
Tare, Rahul S.
587c9db4-e409-4e7c-a02a-677547ab724a
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778

Khan, Ferdous, Smith, James O., Kanczler, Janos M., Tare, Rahul S. and Oreffo, Richard O.C. (2013) Discovery and evaluation of a functional ternary polymer blend for bone repair: translation from a microarry to a clinical model. Advanced Functional Materials, 1-13. (doi:10.1002/adfm.201202710).

Record type: Article

Abstract

Skeletal tissue regeneration is often required following trauma, where substantial bone or cartilage loss may be encountered and is a significant driver for the development of biomaterials with a defined 3D structural network. Solvent blending is a process that avoids complications associated with conventional thermal or mechanical polymer blending or synthesis, opening up large areas of chemical and physical space, while potentially simplifying regulatory pathways towards in vivo application. Here ternary mixtures of natural and synthetic polymers were solvent blended and evaluated as potential bone tissue engineering matrices for osteoregeneration by the assessment of growth and differentiation of STRO-1+ skeletal stem cells. Several of the blend materials were found to be excellent supports for human bone marrow-derived STRO-1+ skeletal cells and fetal skeletal cells, with the optimized blend exhibiting in vivo osteogenic potential, suggesting that these polymer blends could act as suitable matrices for bioengineering of hard tissues.

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More information

e-pub ahead of print date: 25 January 2013
Keywords: biomaterials, skeletal tissue, scaffold, skeletal stem, cells, tissue engineering, polymer blends
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 348660
URI: http://eprints.soton.ac.uk/id/eprint/348660
ISSN: 1616-301X
PURE UUID: febdcf12-2173-44e0-905d-d8bdde83465f
ORCID for Janos M. Kanczler: ORCID iD orcid.org/0000-0001-7249-0414
ORCID for Rahul S. Tare: ORCID iD orcid.org/0000-0001-8274-8837
ORCID for Richard O.C. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

Catalogue record

Date deposited: 15 Feb 2013 13:03
Last modified: 09 Jan 2022 03:19

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Contributors

Author: Ferdous Khan
Author: James O. Smith
Author: Janos M. Kanczler ORCID iD
Author: Rahul S. Tare ORCID iD

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