Effect of a low-protein diet during pregnancy on expression of genes involved in cardiac hypertrophy in fetal and adult mouse offspring
Effect of a low-protein diet during pregnancy on expression of genes involved in cardiac hypertrophy in fetal and adult mouse offspring
Gene markers for cardiomyocyte growth, proliferation and remodeling were examined in mouse fetuses and adult male offspring exposed to maternal low-protein (LP) diet during pregnancy. Whole heart volume, measured by magnetic resonance imaging, was smaller in day 15 LP fetuses v. those from chow-fed dams (C), whereas heart volume was greater in adult LP v. C offspring. These LP offspring were hypertensive and had larger cardiomyocytes v. C animals. The mRNA levels of cyclin G1, a marker for cell growth, were lower in LP fetal hearts v. C hearts, but similar in the left ventricle of adult LP and C offspring. Opposite trends were found in brain natriuretic peptide levels (a marker of cardiac hypertrophy). Thus, maternal LP during pregnancy results in smaller fetal hearts and is accompanied by changes in expression of genes involved in cardiomyocyte growth, which are associated with cardiac hypertrophy and hypertension in adulthood.
bnp, cardiac hypertrophy, cell cycle regulation, cyclin g1, mri
371-375
Asopa, S.
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Cagampang, F.R.
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Anthony, F.W.
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Lanham, S.A.
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Schneider, J.
dc71c85b-9515-470e-8f81-c70bfb08564d
Ohri, Sunil K.
8aa5698c-78cf-4f59-a5af-5afa46f0348c
Hanson, Mark A.
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9 November 2010
Asopa, S.
a6e767da-b59c-461c-96f9-fab2ecf92b0b
Cagampang, F.R.
7cf57d52-4a65-4554-8306-ed65226bc50e
Anthony, F.W.
398b8bed-237e-4fad-a77d-89266fb00bc0
Lanham, S.A.
28fdbbef-e3b6-4fdf-bd0f-4968eeb614d6
Schneider, J.
dc71c85b-9515-470e-8f81-c70bfb08564d
Ohri, Sunil K.
8aa5698c-78cf-4f59-a5af-5afa46f0348c
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Asopa, S., Cagampang, F.R., Anthony, F.W., Lanham, S.A., Schneider, J., Ohri, Sunil K. and Hanson, Mark A.
(2010)
Effect of a low-protein diet during pregnancy on expression of genes involved in cardiac hypertrophy in fetal and adult mouse offspring.
Journal of Developmental Origins of Health and Disease, 1 (6), .
(doi:10.1017/S2040174410000541).
Abstract
Gene markers for cardiomyocyte growth, proliferation and remodeling were examined in mouse fetuses and adult male offspring exposed to maternal low-protein (LP) diet during pregnancy. Whole heart volume, measured by magnetic resonance imaging, was smaller in day 15 LP fetuses v. those from chow-fed dams (C), whereas heart volume was greater in adult LP v. C offspring. These LP offspring were hypertensive and had larger cardiomyocytes v. C animals. The mRNA levels of cyclin G1, a marker for cell growth, were lower in LP fetal hearts v. C hearts, but similar in the left ventricle of adult LP and C offspring. Opposite trends were found in brain natriuretic peptide levels (a marker of cardiac hypertrophy). Thus, maternal LP during pregnancy results in smaller fetal hearts and is accompanied by changes in expression of genes involved in cardiomyocyte growth, which are associated with cardiac hypertrophy and hypertension in adulthood.
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Published date: 9 November 2010
Keywords:
bnp, cardiac hypertrophy, cell cycle regulation, cyclin g1, mri
Organisations:
Human Development & Health
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Local EPrints ID: 348709
URI: http://eprints.soton.ac.uk/id/eprint/348709
PURE UUID: a9733b8b-dd79-4101-b5f7-4313987b2ade
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Date deposited: 18 Feb 2013 15:13
Last modified: 15 Mar 2024 03:14
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Author:
S. Asopa
Author:
F.W. Anthony
Author:
S.A. Lanham
Author:
J. Schneider
Author:
Sunil K. Ohri
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