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Plasma exchange in the management of a case of hypertriglyceridaemic pancreatitis triggered by venlafaxine

Record type: Article

The authors present a case of a young, non-diabetic Caucasian male patient with long-standing depression who had recently been started on venlafaxine. He presented to the emergency department with central abdominal pain, drowsiness and vomiting with a raised serum amylase. He was diagnosed with acute pancreatitis (AP) that was confirmed following an abdominal ultrasound and CT. His initial biochemistry was immeasurable in the first 12 h of admission due to macroscopically visible hyperlipidaemia. In the absence of any other causes of AP, hyperlipidaemia was the most likely aetiology. He was transferred to the intensive care unit where he was managed by lipidic restriction, fluid resuscitation and 3 consecutive days of plasma exchange. Plasma triglyceride levels were reduced from 42.9 to 2.4 mmol/l following plasma exchange. He made a full recovery and at discharge was investigated for familial hypertriglyceridaemia and referred to a multi-disciplinary team for follow-up. His venlafaxine was stopped on admission.

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Sevastru, Stefan, Wakatsuki, Mai, Fennell, Jonathan and Grocott, Michael P.W. (2012) Plasma exchange in the management of a case of hypertriglyceridaemic pancreatitis triggered by venlafaxine BMJ Case Reports, 2012 (doi:10.1136/bcr.11.2011.5208). (PMID:22892234).

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Published date: 2012
Organisations: Human Development & Health


Local EPrints ID: 348857
ISSN: 1757-790X
PURE UUID: 7a650bea-fe2a-452f-acac-51d1fa46bd46

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Date deposited: 21 Feb 2013 12:16
Last modified: 18 Jul 2017 04:47

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Author: Stefan Sevastru
Author: Mai Wakatsuki
Author: Jonathan Fennell

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