Levett, Denny Z.H., Martin, Daniel S., Wilson, Mark H., Mitchell, Kay, Dhillon, Sundeep, Rigat, Fabio, Montgomery, Hugh E., Mythen, Monty G. and Grocott, Michael P.W.
Design and conduct of Caudwell Xtreme Everest: an observational cohort study of variation in human adaptation to progressive environmental hypoxia
BMC Medical Research Methodology, 10, . (doi:10.1186/1471-2288-10-98). (PMID:20964858).
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This study demonstrates the feasibility and safety of conducting a large healthy volunteer cohort study of human adaptation to hypoxia in this difficult environment. Systematic measurements of a large set of variables were achieved in 222 subjects and at altitudes up to 8400 m. The resulting dataset is a unique resource for the study of genotype:phenotype interactions in relation to hypoxic adaptation.
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