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The effect of high-altitude on human skeletal muscle energetics: P-MRS results from the Caudwell Xtreme Everest expedition.

Record type: Article

Many disease states are associated with regional or systemic hypoxia. The study of healthy individuals exposed to high-altitude hypoxia offers a way to explore hypoxic adaptation without the confounding effects of disease and therapeutic interventions. Using (31)P magnetic resonance spectroscopy and imaging, we investigated skeletal muscle energetics and morphology after exposure to hypobaric hypoxia in seven altitude-naïve subjects (trekkers) and seven experienced climbers. The trekkers ascended to 5300 m while the climbers ascended above 7950 m. Before the study, climbers had better mitochondrial function (evidenced by shorter phosphocreatine recovery halftime) than trekkers: 16+/-1 vs. 22+/-2 s (mean +/- SE, p<0.01). Climbers had higher resting [Pi] than trekkers before the expedition and resting [Pi] was raised across both groups on their return (PRE: 2.6+/-0.2 vs. POST: 3.0+/-0.2 mM, p<0.05). There was significant muscle atrophy post-CXE (PRE: 4.7+/-0.2 vs. POST: 4.5+/-0.2 cm(2), p<0.05), yet exercising metabolites were unchanged. These results suggest that, in response to high altitude hypoxia, skeletal muscle function is maintained in humans, despite significant atrophy.

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Citation

Edwards, Lindsay M., Murray, Andrew J., Tyler, Damian J., Kemp, Graham J., Holloway, Cameron J., Robbins, Peter A., Neubauer, Stefan, Levett, Denny, Montgomery, Hugh E., Grocott, Mike P.W. and Clarke, Kieran (2010) The effect of high-altitude on human skeletal muscle energetics: P-MRS results from the Caudwell Xtreme Everest expedition. PLoS ONE, 5, (5), e10681. (doi:10.1371/journal.pone.0010681). (PMID:20502713).

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Published date: 19 May 2010
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 348902
URI: http://eprints.soton.ac.uk/id/eprint/348902
ISSN: 1932-6203
PURE UUID: b259b75c-2afb-4eb7-86b1-3ef3e968ebea

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Date deposited: 25 Feb 2013 14:07
Last modified: 18 Jul 2017 04:46

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Contributors

Author: Lindsay M. Edwards
Author: Andrew J. Murray
Author: Damian J. Tyler
Author: Graham J. Kemp
Author: Cameron J. Holloway
Author: Peter A. Robbins
Author: Stefan Neubauer
Author: Denny Levett
Author: Hugh E. Montgomery
Author: Kieran Clarke

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