Abnormal blood flow in the sublingual microcirculation at high altitude

Martin, Daniel S., Ince, Can, Goedhart, Peter, Levett, Denny Z.H. and Grocott, Mike P.W. Caudwell Xtreme Everest Research Group (2009) Abnormal blood flow in the sublingual microcirculation at high altitude European Journal of Applied Physiology, 106, (3), pp. 473-478. (doi:10.1007/s00421-009-1023-8). (PMID:15343008).


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We report the first direct observations of deranged microcirculatory blood flow at high altitude, using sidestream dark-field imaging. Images of the sublingual microcirculation were obtained from a group of 12 volunteers during a climbing expedition to Cho Oyu (8,201 m) in the Himalayas. Microcirculatory flow index (MFI) was calculated from the moving images of microcirculatory red blood cell flow, and comparison was made between the baseline and high altitude measurements. Peripheral oxygen saturation (SpO(2)) and Lake Louise scores (LLS) were recorded along with MFI. Our data demonstrate that there was a significant reduction in MFI from baseline to 4,900 m in small (less than 25 microm) and medium (26-50 microm) sized blood vessels (P = 0.025 and P = 0.046, respectively). There was no significant correlation between MFI and SpO(2) or MFI and LLS. Disruption of blood flow within microcirculatory may explain persistent abnormal oxygen flux to tissues following the normalisation of systemic oxygen delivery that accompanies acclimatisation to high altitude.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1007/s00421-009-1023-8
ISSNs: 1439-6319 (print)
Subjects: Q Science > QP Physiology
Organisations: Human Development & Health
ePrint ID: 348930
Date :
Date Event
June 2009Published
Date Deposited: 22 Feb 2013 11:45
Last Modified: 17 Apr 2017 15:58
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/348930

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