Genetophysiology: using genetic strategies to explore hypoxic adaptation
Genetophysiology: using genetic strategies to explore hypoxic adaptation
The common inheritance of the same 20,000 to 25,000 genes defines us as human. However, substantial variation exists in the human genome, which determines how each of us will respond to any given (identical) environmental stimulus. The interaction of this variation with diverse environmental stimuli makes us all different from one another. Rapid advances in the sequencing of the human genome and in the description of the common variation within it will help us identify genes and pathways that regulate hypoxic (mal)adaptation. The resultant knowledge will be of relevance not only to mountaineers: many disease states are complicated by low cellular oxygen availability, and a grasp of the mechanisms through which adaptation occurs will offer new therapeutic targets.
123-129
Grocott, Mike
1e87b741-513e-4a22-be13-0f7bb344e8c2
Montgomery, Hugh
ec760637-aea7-43be-98d1-71a1f72e6efa
June 2008
Grocott, Mike
1e87b741-513e-4a22-be13-0f7bb344e8c2
Montgomery, Hugh
ec760637-aea7-43be-98d1-71a1f72e6efa
Grocott, Mike and Montgomery, Hugh
(2008)
Genetophysiology: using genetic strategies to explore hypoxic adaptation.
High Altitude Medicine & Biology, 9 (2), .
(doi:10.1089/ham.2008.1012).
(PMID:18578643)
Abstract
The common inheritance of the same 20,000 to 25,000 genes defines us as human. However, substantial variation exists in the human genome, which determines how each of us will respond to any given (identical) environmental stimulus. The interaction of this variation with diverse environmental stimuli makes us all different from one another. Rapid advances in the sequencing of the human genome and in the description of the common variation within it will help us identify genes and pathways that regulate hypoxic (mal)adaptation. The resultant knowledge will be of relevance not only to mountaineers: many disease states are complicated by low cellular oxygen availability, and a grasp of the mechanisms through which adaptation occurs will offer new therapeutic targets.
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Published date: June 2008
Organisations:
Human Development & Health
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Local EPrints ID: 348935
URI: http://eprints.soton.ac.uk/id/eprint/348935
ISSN: 1527-0297
PURE UUID: 553f766f-8eea-47b8-8fe5-4926aa6ebede
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Date deposited: 22 Feb 2013 14:28
Last modified: 15 Mar 2024 03:33
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Author:
Hugh Montgomery
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