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Increased gastric-end tidal P(CO2) gap during exercise at high altitude measured by gastric tonometry

Martin, Daniel, McCorkell, Stuart, Vercueil, Andre, Gunning, Paul, Cox, Mark, Dick, John, Mythen, Monty and Grocott, Mike (2007) Increased gastric-end tidal P(CO2) gap during exercise at high altitude measured by gastric tonometry High Altitude Medicine & Biology, 8, (1), pp. 50-55. (doi:10.1089/ham.2006.1022). (PMID:17394417).

Record type: Article


Using automated air gastric tonometry, the hypothesis that gastric perfusion is reduced while exercising at high altitude was explored. This prospective observational study of 5 well acclimatized healthy volunteers was performed during a medical research expedition to Chamlang base camp (5000 m), Hongu valley, Nepal. We used gastric tonometry at rest and during graded submaximal exercise. The end tidal partial pressure of carbon dioxide was subtracted from the gastric mucosal partial pressure of carbon dioxide to calculate the P(CO2) gradient, which is a marker of gastric mucosal perfusion. When compared with rest, there was no increase in the mean P(CO2) gradient at the lower work rate (0.22 vs. 0.18, p 0.10), but an increase was seen between rest and the higher work rate (0.22 vs. 0.77, p = 0.04). We conclude that exercising while at high altitude can lead to a raised P(CO2) gradient when gastric tonometry is performed, indicating reduced perfusion. This may represent reduced gastric mucosal perfusion under these conditions.

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Published date: 29 March 2007
Organisations: Human Development & Health


Local EPrints ID: 348945
ISSN: 1527-0297
PURE UUID: d71176bb-3783-4171-bd96-f1f262906bbd

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Date deposited: 04 Mar 2013 14:25
Last modified: 18 Jul 2017 04:46

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Author: Daniel Martin
Author: Stuart McCorkell
Author: Andre Vercueil
Author: Paul Gunning
Author: Mark Cox
Author: John Dick
Author: Monty Mythen
Author: Mike Grocott

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