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Increased gastric-end tidal P(CO2) gap during exercise at high altitude measured by gastric tonometry

Increased gastric-end tidal P(CO2) gap during exercise at high altitude measured by gastric tonometry
Increased gastric-end tidal P(CO2) gap during exercise at high altitude measured by gastric tonometry
Using automated air gastric tonometry, the hypothesis that gastric perfusion is reduced while exercising at high altitude was explored. This prospective observational study of 5 well acclimatized healthy volunteers was performed during a medical research expedition to Chamlang base camp (5000 m), Hongu valley, Nepal. We used gastric tonometry at rest and during graded submaximal exercise. The end tidal partial pressure of carbon dioxide was subtracted from the gastric mucosal partial pressure of carbon dioxide to calculate the P(CO2) gradient, which is a marker of gastric mucosal perfusion. When compared with rest, there was no increase in the mean P(CO2) gradient at the lower work rate (0.22 vs. 0.18, p 0.10), but an increase was seen between rest and the higher work rate (0.22 vs. 0.77, p = 0.04). We conclude that exercising while at high altitude can lead to a raised P(CO2) gradient when gastric tonometry is performed, indicating reduced perfusion. This may represent reduced gastric mucosal perfusion under these conditions.
1527-0297
50-55
Martin, Daniel
3e441b48-9221-4308-8ae6-49cbde20753f
McCorkell, Stuart
e692b1a7-978b-4f5d-a62a-1f9190edc6ec
Vercueil, Andre
2c8603fa-d72f-47ab-9cda-3a15f8e49867
Gunning, Paul
913081a2-f84f-4fda-9cbf-02c5e09a4c69
Cox, Mark
0bc83597-07a4-4103-97c6-60626dc1628e
Dick, John
c3a96086-3861-4cde-bb5c-5b2f6467bab9
Mythen, Monty
ced4210c-1c97-4e00-aa51-58dea2959848
Grocott, Mike
1e87b741-513e-4a22-be13-0f7bb344e8c2
Martin, Daniel
3e441b48-9221-4308-8ae6-49cbde20753f
McCorkell, Stuart
e692b1a7-978b-4f5d-a62a-1f9190edc6ec
Vercueil, Andre
2c8603fa-d72f-47ab-9cda-3a15f8e49867
Gunning, Paul
913081a2-f84f-4fda-9cbf-02c5e09a4c69
Cox, Mark
0bc83597-07a4-4103-97c6-60626dc1628e
Dick, John
c3a96086-3861-4cde-bb5c-5b2f6467bab9
Mythen, Monty
ced4210c-1c97-4e00-aa51-58dea2959848
Grocott, Mike
1e87b741-513e-4a22-be13-0f7bb344e8c2

Martin, Daniel, McCorkell, Stuart, Vercueil, Andre, Gunning, Paul, Cox, Mark, Dick, John, Mythen, Monty and Grocott, Mike (2007) Increased gastric-end tidal P(CO2) gap during exercise at high altitude measured by gastric tonometry. High Altitude Medicine & Biology, 8 (1), 50-55. (doi:10.1089/ham.2006.1022). (PMID:17394417)

Record type: Article

Abstract

Using automated air gastric tonometry, the hypothesis that gastric perfusion is reduced while exercising at high altitude was explored. This prospective observational study of 5 well acclimatized healthy volunteers was performed during a medical research expedition to Chamlang base camp (5000 m), Hongu valley, Nepal. We used gastric tonometry at rest and during graded submaximal exercise. The end tidal partial pressure of carbon dioxide was subtracted from the gastric mucosal partial pressure of carbon dioxide to calculate the P(CO2) gradient, which is a marker of gastric mucosal perfusion. When compared with rest, there was no increase in the mean P(CO2) gradient at the lower work rate (0.22 vs. 0.18, p 0.10), but an increase was seen between rest and the higher work rate (0.22 vs. 0.77, p = 0.04). We conclude that exercising while at high altitude can lead to a raised P(CO2) gradient when gastric tonometry is performed, indicating reduced perfusion. This may represent reduced gastric mucosal perfusion under these conditions.

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More information

Published date: 29 March 2007
Organisations: Human Development & Health

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Local EPrints ID: 348945
URI: http://eprints.soton.ac.uk/id/eprint/348945
ISSN: 1527-0297
PURE UUID: d71176bb-3783-4171-bd96-f1f262906bbd
ORCID for Mike Grocott: ORCID iD orcid.org/0000-0002-9484-7581

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Date deposited: 04 Mar 2013 14:25
Last modified: 15 Mar 2024 03:33

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Contributors

Author: Daniel Martin
Author: Stuart McCorkell
Author: Andre Vercueil
Author: Paul Gunning
Author: Mark Cox
Author: John Dick
Author: Monty Mythen
Author: Mike Grocott ORCID iD

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