Increased gastric-end tidal P(CO2) gap during exercise at high altitude measured by gastric tonometry


Martin, Daniel, McCorkell, Stuart, Vercueil, Andre, Gunning, Paul, Cox, Mark, Dick, John, Mythen, Monty and Grocott, Mike (2007) Increased gastric-end tidal P(CO2) gap during exercise at high altitude measured by gastric tonometry High Altitude Medicine & Biology, 8, (1), pp. 50-55. (doi:10.1089/ham.2006.1022). (PMID:17394417).

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Description/Abstract

Using automated air gastric tonometry, the hypothesis that gastric perfusion is reduced while exercising at high altitude was explored. This prospective observational study of 5 well acclimatized healthy volunteers was performed during a medical research expedition to Chamlang base camp (5000 m), Hongu valley, Nepal. We used gastric tonometry at rest and during graded submaximal exercise. The end tidal partial pressure of carbon dioxide was subtracted from the gastric mucosal partial pressure of carbon dioxide to calculate the P(CO2) gradient, which is a marker of gastric mucosal perfusion. When compared with rest, there was no increase in the mean P(CO2) gradient at the lower work rate (0.22 vs. 0.18, p 0.10), but an increase was seen between rest and the higher work rate (0.22 vs. 0.77, p = 0.04). We conclude that exercising while at high altitude can lead to a raised P(CO2) gradient when gastric tonometry is performed, indicating reduced perfusion. This may represent reduced gastric mucosal perfusion under these conditions.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1089/ham.2006.1022
ISSNs: 1527-0297 (print)
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Organisations: Human Development & Health
ePrint ID: 348945
Date :
Date Event
29 March 2007Published
Date Deposited: 04 Mar 2013 14:25
Last Modified: 21 Feb 2017 15:57
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/348945

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