High-altitude physiology and pathophysiology: implications and relevance for intensive care medicine
High-altitude physiology and pathophysiology: implications and relevance for intensive care medicine
Cellular hypoxia is a fundamental mechanism of injury in the critically ill. The study of human responses to hypoxia occurring as a consequence of hypobaria defines the fields of high-altitude medicine and physiology. A new paradigm suggests that the physiological and pathophysiological responses to extreme environmental challenges (for example, hypobaric hypoxia, hyperbaria, microgravity, cold, heat) may be similar to responses seen in critical illness. The present review explores the idea that human responses to the hypoxia of high altitude may be used as a means of exploring elements of the pathophysiology of critical illness.
203
Grocott, Michael
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Montgomery, Hugh
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Vercueil, Andre
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February 2007
Grocott, Michael
1e87b741-513e-4a22-be13-0f7bb344e8c2
Montgomery, Hugh
ec760637-aea7-43be-98d1-71a1f72e6efa
Vercueil, Andre
2c8603fa-d72f-47ab-9cda-3a15f8e49867
Grocott, Michael, Montgomery, Hugh and Vercueil, Andre
(2007)
High-altitude physiology and pathophysiology: implications and relevance for intensive care medicine.
Critical Care, 11 (203), .
(doi:10.1186/cc5142).
(PMID:17291330)
Abstract
Cellular hypoxia is a fundamental mechanism of injury in the critically ill. The study of human responses to hypoxia occurring as a consequence of hypobaria defines the fields of high-altitude medicine and physiology. A new paradigm suggests that the physiological and pathophysiological responses to extreme environmental challenges (for example, hypobaric hypoxia, hyperbaria, microgravity, cold, heat) may be similar to responses seen in critical illness. The present review explores the idea that human responses to the hypoxia of high altitude may be used as a means of exploring elements of the pathophysiology of critical illness.
Text
art%253A10.1186%252Fcc5142
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Published date: February 2007
Organisations:
Human Development & Health
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Local EPrints ID: 348948
URI: http://eprints.soton.ac.uk/id/eprint/348948
ISSN: 1364-8535
PURE UUID: dacfeacb-c630-4647-ba84-3cf105cabdb6
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Date deposited: 27 Feb 2013 10:02
Last modified: 15 Mar 2024 03:33
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Author:
Hugh Montgomery
Author:
Andre Vercueil
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