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High-altitude physiology and pathophysiology: implications and relevance for intensive care medicine

Grocott, Michael, Montgomery, Hugh and Vercueil, Andre (2007) High-altitude physiology and pathophysiology: implications and relevance for intensive care medicine Critical Care, 11, (203), p. 203. (doi:10.1186/cc5142). (PMID:17291330).

Record type: Article


Cellular hypoxia is a fundamental mechanism of injury in the critically ill. The study of human responses to hypoxia occurring as a consequence of hypobaria defines the fields of high-altitude medicine and physiology. A new paradigm suggests that the physiological and pathophysiological responses to extreme environmental challenges (for example, hypobaric hypoxia, hyperbaria, microgravity, cold, heat) may be similar to responses seen in critical illness. The present review explores the idea that human responses to the hypoxia of high altitude may be used as a means of exploring elements of the pathophysiology of critical illness.

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Published date: February 2007
Organisations: Human Development & Health


Local EPrints ID: 348948
ISSN: 1364-8535
PURE UUID: dacfeacb-c630-4647-ba84-3cf105cabdb6

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Date deposited: 27 Feb 2013 10:02
Last modified: 18 Jul 2017 04:46

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Author: Michael Grocott
Author: Hugh Montgomery
Author: Andre Vercueil

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