A descriptive study of the variation in baseline levels of antiendotoxin core antibodies between US and UK populations


Down, J.F., Barclay, G.R., Bennett-Guerrero, E., Hamilton-Davies, C., Stephens, R., Grocott, M.P.W. and Mythen, M.G. (2004) A descriptive study of the variation in baseline levels of antiendotoxin core antibodies between US and UK populations Journal of Endotoxin Research, 10, (3), pp. 195-196. (doi:10.1177/09680519040100030601). (PMID:15198854).

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Description/Abstract

Low levels of naturally occurring antibodies to the core section of endotoxin (EndoCAb) have been shown to be predictors of poor outcome following major surgery. We performed a retrospective study comparing pre-operative levels in US surgical patients, UK surgical patients and healthy volunteers. Both IgM and IgG EndoCAb levels were higher in the US surgical patients when compared with the other groups (approximately twice as high in the case of IgG EndoCAb). This may reflect genetic or environmental variability between the patient groups, differences in the disease processes, the disparity in the delivery of health care between the two countries or degradation of the samples in transfer.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1177/09680519040100030601
ISSNs: 0968-0519 (print)
Keywords: antibodies, endotoxin core, variations, populations
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > RD Surgery
Organisations: Human Development & Health
ePrint ID: 348961
Date :
Date Event
June 2004Published
Date Deposited: 05 Mar 2013 12:13
Last Modified: 21 Feb 2017 15:49
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/348961

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