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A descriptive study of the variation in baseline levels of antiendotoxin core antibodies between US and UK populations

A descriptive study of the variation in baseline levels of antiendotoxin core antibodies between US and UK populations
A descriptive study of the variation in baseline levels of antiendotoxin core antibodies between US and UK populations
Low levels of naturally occurring antibodies to the core section of endotoxin (EndoCAb) have been shown to be predictors of poor outcome following major surgery. We performed a retrospective study comparing pre-operative levels in US surgical patients, UK surgical patients and healthy volunteers. Both IgM and IgG EndoCAb levels were higher in the US surgical patients when compared with the other groups (approximately twice as high in the case of IgG EndoCAb). This may reflect genetic or environmental variability between the patient groups, differences in the disease processes, the disparity in the delivery of health care between the two countries or degradation of the samples in transfer.
antibodies, endotoxin core, variations, populations
0968-0519
195-196
Down, J.F.
7702b1de-8536-4fd9-8b65-74c7d1f69681
Barclay, G.R.
cc1ce3b1-8865-4a24-b7c7-9dd7c8835819
Bennett-Guerrero, E.
dca4fe96-2f40-4653-9757-8725d0ad124a
Hamilton-Davies, C.
a681a848-6bb1-4af0-9516-b268a16ba771
Stephens, R.
83fb2a3a-eb0c-46d1-8a3f-eb772ce0ecdc
Grocott, M.P.W.
1e87b741-513e-4a22-be13-0f7bb344e8c2
Mythen, M.G.
c82ab585-86d5-44f8-bd3c-ead87c59d459
Down, J.F.
7702b1de-8536-4fd9-8b65-74c7d1f69681
Barclay, G.R.
cc1ce3b1-8865-4a24-b7c7-9dd7c8835819
Bennett-Guerrero, E.
dca4fe96-2f40-4653-9757-8725d0ad124a
Hamilton-Davies, C.
a681a848-6bb1-4af0-9516-b268a16ba771
Stephens, R.
83fb2a3a-eb0c-46d1-8a3f-eb772ce0ecdc
Grocott, M.P.W.
1e87b741-513e-4a22-be13-0f7bb344e8c2
Mythen, M.G.
c82ab585-86d5-44f8-bd3c-ead87c59d459

Down, J.F., Barclay, G.R., Bennett-Guerrero, E., Hamilton-Davies, C., Stephens, R., Grocott, M.P.W. and Mythen, M.G. (2004) A descriptive study of the variation in baseline levels of antiendotoxin core antibodies between US and UK populations. Journal of Endotoxin Research, 10 (3), 195-196. (doi:10.1177/09680519040100030601). (PMID:15198854)

Record type: Article

Abstract

Low levels of naturally occurring antibodies to the core section of endotoxin (EndoCAb) have been shown to be predictors of poor outcome following major surgery. We performed a retrospective study comparing pre-operative levels in US surgical patients, UK surgical patients and healthy volunteers. Both IgM and IgG EndoCAb levels were higher in the US surgical patients when compared with the other groups (approximately twice as high in the case of IgG EndoCAb). This may reflect genetic or environmental variability between the patient groups, differences in the disease processes, the disparity in the delivery of health care between the two countries or degradation of the samples in transfer.

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More information

Published date: June 2004
Keywords: antibodies, endotoxin core, variations, populations
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 348961
URI: http://eprints.soton.ac.uk/id/eprint/348961
ISSN: 0968-0519
PURE UUID: 90500d25-47cf-41e4-83c1-7d51ac009514
ORCID for M.P.W. Grocott: ORCID iD orcid.org/0000-0002-9484-7581

Catalogue record

Date deposited: 05 Mar 2013 12:13
Last modified: 04 Oct 2019 00:34

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