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A descriptive study of the variation in baseline levels of antiendotoxin core antibodies between US and UK populations

Record type: Article

Low levels of naturally occurring antibodies to the core section of endotoxin (EndoCAb) have been shown to be predictors of poor outcome following major surgery. We performed a retrospective study comparing pre-operative levels in US surgical patients, UK surgical patients and healthy volunteers. Both IgM and IgG EndoCAb levels were higher in the US surgical patients when compared with the other groups (approximately twice as high in the case of IgG EndoCAb). This may reflect genetic or environmental variability between the patient groups, differences in the disease processes, the disparity in the delivery of health care between the two countries or degradation of the samples in transfer.

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Citation

Down, J.F., Barclay, G.R., Bennett-Guerrero, E., Hamilton-Davies, C., Stephens, R., Grocott, M.P.W. and Mythen, M.G. (2004) A descriptive study of the variation in baseline levels of antiendotoxin core antibodies between US and UK populations Journal of Endotoxin Research, 10, (3), pp. 195-196. (doi:10.1177/09680519040100030601). (PMID:15198854).

More information

Published date: June 2004
Keywords: antibodies, endotoxin core, variations, populations
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 348961
URI: http://eprints.soton.ac.uk/id/eprint/348961
ISSN: 0968-0519
PURE UUID: 90500d25-47cf-41e4-83c1-7d51ac009514

Catalogue record

Date deposited: 05 Mar 2013 12:13
Last modified: 18 Jul 2017 04:45

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Contributors

Author: J.F. Down
Author: G.R. Barclay
Author: E. Bennett-Guerrero
Author: C. Hamilton-Davies
Author: R. Stephens
Author: M.P.W. Grocott
Author: M.G. Mythen

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