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Review on the development of truly portable and in-situ capillary electrophoresis systems

Review on the development of truly portable and in-situ capillary electrophoresis systems
Review on the development of truly portable and in-situ capillary electrophoresis systems
Capillary electrophoresis (CE) is a technique which uses an electric field to separate a mixed sample into its constituents. Portable CE systems enable this powerful analysis technique to be used in the field. Many of the challenges for portable systems are similar to those of autonomous in-situ analysis and therefore portable systems may be considered a stepping stone towards autonomous in-situ analysis. CE is widely used for biological and chemical analysis and example applications include: water quality analysis; drug development and quality control; proteomics and DNA analysis; counter-terrorism (explosive material identification) and corrosion monitoring. The technique is often limited to laboratory use, since it requires large electric fields, sensitive detection systems and fluidic control systems. All of these place restrictions in terms of: size, weight, cost, choice of operating solutions, choice of fabrication materials, electrical power and lifetime. In this review we bring together and critique the work by researchers addressing these issues. We emphasize the importance of a holistic approach for portable and in-situ CE systems and discuss all the aspects of the design. We identify gaps in the literature which require attention for the realization of both truly portable and in-situ CE systems.
capillary electrophoresis, portable, in-situ, micro?uidics, lab-on-a-chip, point-of-care, environmental monitoring, environmental analysis, micro-total analysis systems, portable high voltage power supplies, sample injection schemes
1361-6501
1-20
Lewis, Adam
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Cranny, Andy
2ebc2ccb-7d3e-4a6a-91ac-9f089741939e
Harris, Nick
237cfdbd-86e4-4025-869c-c85136f14dfd
Green, Nicolas G
d9b47269-c426-41fd-a41d-5f4579faa581
Wharton, Julian A.
965a38fd-d2bc-4a19-a08c-2d4e036aa96b
Wood, R.J.K.
d9523d31-41a8-459a-8831-70e29ffe8a73
Stokes, Keith R.
5fb4e7f7-2f7e-4e6e-a045-6d7690626695
Lewis, Adam
92717168-ccc3-4540-8150-6e42198ae454
Cranny, Andy
2ebc2ccb-7d3e-4a6a-91ac-9f089741939e
Harris, Nick
237cfdbd-86e4-4025-869c-c85136f14dfd
Green, Nicolas G
d9b47269-c426-41fd-a41d-5f4579faa581
Wharton, Julian A.
965a38fd-d2bc-4a19-a08c-2d4e036aa96b
Wood, R.J.K.
d9523d31-41a8-459a-8831-70e29ffe8a73
Stokes, Keith R.
5fb4e7f7-2f7e-4e6e-a045-6d7690626695

Lewis, Adam, Cranny, Andy, Harris, Nick, Green, Nicolas G, Wharton, Julian A., Wood, R.J.K. and Stokes, Keith R. (2013) Review on the development of truly portable and in-situ capillary electrophoresis systems. Measurement Science and Technology, 24 (4), 1-20. (doi:10.1088/0957-0233/24/4/042001).

Record type: Article

Abstract

Capillary electrophoresis (CE) is a technique which uses an electric field to separate a mixed sample into its constituents. Portable CE systems enable this powerful analysis technique to be used in the field. Many of the challenges for portable systems are similar to those of autonomous in-situ analysis and therefore portable systems may be considered a stepping stone towards autonomous in-situ analysis. CE is widely used for biological and chemical analysis and example applications include: water quality analysis; drug development and quality control; proteomics and DNA analysis; counter-terrorism (explosive material identification) and corrosion monitoring. The technique is often limited to laboratory use, since it requires large electric fields, sensitive detection systems and fluidic control systems. All of these place restrictions in terms of: size, weight, cost, choice of operating solutions, choice of fabrication materials, electrical power and lifetime. In this review we bring together and critique the work by researchers addressing these issues. We emphasize the importance of a holistic approach for portable and in-situ CE systems and discuss all the aspects of the design. We identify gaps in the literature which require attention for the realization of both truly portable and in-situ CE systems.

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Published date: 22 February 2013
Keywords: capillary electrophoresis, portable, in-situ, micro?uidics, lab-on-a-chip, point-of-care, environmental monitoring, environmental analysis, micro-total analysis systems, portable high voltage power supplies, sample injection schemes
Organisations: Electronics & Computer Science

Identifiers

Local EPrints ID: 349139
URI: http://eprints.soton.ac.uk/id/eprint/349139
ISSN: 1361-6501
PURE UUID: 12d7a835-1830-43d3-a9b0-d66a233bae4d
ORCID for Nick Harris: ORCID iD orcid.org/0000-0003-4122-2219
ORCID for Nicolas G Green: ORCID iD orcid.org/0000-0001-9230-4455
ORCID for Julian A. Wharton: ORCID iD orcid.org/0000-0002-3439-017X
ORCID for R.J.K. Wood: ORCID iD orcid.org/0000-0003-0681-9239

Catalogue record

Date deposited: 26 Feb 2013 14:37
Last modified: 18 Feb 2021 17:03

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