The University of Southampton
University of Southampton Institutional Repository

Early life stress and blood pressure levels in late adulthood

Early life stress and blood pressure levels in late adulthood
Early life stress and blood pressure levels in late adulthood
Severe stress experienced in early life may have long-term consequences on adult physiological functions. We studied the long-term effects of separation on blood pressure levels in non-obese subjects who were separated temporarily in childhood from their parents during World War II (WWII). The original clinical study cohort consists of people born during 1934–1944 in Helsinki, Finland. This substudy includes 1361 non-obese subjects (body mass index <30?kg?m?2). Of these, 192 (14.1%) had been evacuated abroad during WWII. The remaining subjects served as controls. Blood pressure levels and use of blood pressure medication were studied. The separated subjects had significantly higher systolic blood pressure values than the non-separated (148.6+21.5 vs 142.2+19.6?mm?Hg, P<0.0001) in adult life. Those subjects separated in early childhood had markedly higher systolic and diastolic blood pressure values in adult life compared with the non-separated (154.6 vs 142.5?mm?Hg; 95% confidence interval (CI) 2.6–14.7; P<0.005 and 90.8 vs 87.7?mm?Hg; 95% CI 1.0–7.3; P<0.02, respectively). Systolic blood pressure was also higher in the group separated for a duration of <1 year (151.7 vs 142.2?mm?Hg; 95% CI 0.0–12.4; P<0.05) compared with the non-separated. Besides being separated, age at separation and duration of separation also influenced blood pressure levels in adult life. This could be due to early hormonal and metabolic programming, during plastic periods in early life, influencing blood pressure levels in adult life.
0950-9240
90-94
Alastalo, H.
4a664e82-55e2-426a-94ad-a2fd66c3665f
Raikkonen, K.
926aba17-06cd-417b-b20f-ae400a2596a6
Pesonen, A.K.
edd22dbe-e07d-4212-a476-aaff63f619f5
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Heinonen, K.
667793ce-59c1-43d0-9f53-4f7790a9ed94
Kajantie, E.
d4e32f85-9988-4b83-b353-012210ea0151
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b
Alastalo, H.
4a664e82-55e2-426a-94ad-a2fd66c3665f
Raikkonen, K.
926aba17-06cd-417b-b20f-ae400a2596a6
Pesonen, A.K.
edd22dbe-e07d-4212-a476-aaff63f619f5
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Heinonen, K.
667793ce-59c1-43d0-9f53-4f7790a9ed94
Kajantie, E.
d4e32f85-9988-4b83-b353-012210ea0151
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b

Alastalo, H., Raikkonen, K., Pesonen, A.K., Osmond, C., Heinonen, K., Kajantie, E. and Eriksson, J.G. (2013) Early life stress and blood pressure levels in late adulthood. Journal of Human Hypertension, 27 (2), 90-94. (doi:10.1038/jhh.2012.6). (PMID:22336905)

Record type: Article

Abstract

Severe stress experienced in early life may have long-term consequences on adult physiological functions. We studied the long-term effects of separation on blood pressure levels in non-obese subjects who were separated temporarily in childhood from their parents during World War II (WWII). The original clinical study cohort consists of people born during 1934–1944 in Helsinki, Finland. This substudy includes 1361 non-obese subjects (body mass index <30?kg?m?2). Of these, 192 (14.1%) had been evacuated abroad during WWII. The remaining subjects served as controls. Blood pressure levels and use of blood pressure medication were studied. The separated subjects had significantly higher systolic blood pressure values than the non-separated (148.6+21.5 vs 142.2+19.6?mm?Hg, P<0.0001) in adult life. Those subjects separated in early childhood had markedly higher systolic and diastolic blood pressure values in adult life compared with the non-separated (154.6 vs 142.5?mm?Hg; 95% confidence interval (CI) 2.6–14.7; P<0.005 and 90.8 vs 87.7?mm?Hg; 95% CI 1.0–7.3; P<0.02, respectively). Systolic blood pressure was also higher in the group separated for a duration of <1 year (151.7 vs 142.2?mm?Hg; 95% CI 0.0–12.4; P<0.05) compared with the non-separated. Besides being separated, age at separation and duration of separation also influenced blood pressure levels in adult life. This could be due to early hormonal and metabolic programming, during plastic periods in early life, influencing blood pressure levels in adult life.

Full text not available from this repository.

More information

Published date: February 2013
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 349195
URI: https://eprints.soton.ac.uk/id/eprint/349195
ISSN: 0950-9240
PURE UUID: ef74802f-46a1-4896-b179-e9d45285e4db
ORCID for C. Osmond: ORCID iD orcid.org/0000-0002-9054-4655

Catalogue record

Date deposited: 26 Feb 2013 15:08
Last modified: 06 Jun 2018 13:04

Export record

Altmetrics

Contributors

Author: H. Alastalo
Author: K. Raikkonen
Author: A.K. Pesonen
Author: C. Osmond ORCID iD
Author: K. Heinonen
Author: E. Kajantie
Author: J.G. Eriksson

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×