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Is lung function associated with bone mineral density? results from the Hertfordshire Cohort Study

Is lung function associated with bone mineral density? results from the Hertfordshire Cohort Study
Is lung function associated with bone mineral density? results from the Hertfordshire Cohort Study
Summary
Given limited information available regarding associations between lung function and bone mineral density among healthy subjects, we undertook these analyses in the Hertfordshire Cohort Study. Forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC were not associated with bone mineral density at any site; associations with bone mineral content were removed by adjustment for body size.

Purpose
There is limited information available regarding the association between lung function and bone mineral density among healthy elderly subjects. We addressed this issue in the Hertfordshire Cohort Study.

Methods
From the above cohort, 985 subjects (496 men and 489 women) aged 60–72 years were recruited. All subjects underwent bone density measurements using dual energy X-ray absorptiometry and lung function tests using standardised spirometry. Chronic obstructive pulmonary disease (COPD) was defined as a FEV1/FVC ratio <lower limit of normal, calculated using separate equations for men and women.

Results
Measures of lung function (FEV1, FVC and FEV1/FVC) were not associated with bone mineral density at the lumbar spine, femoral neck and total hip in men or women; associations with bone mineral content and bone area were removed by adjustment for body size and lifestyle confounders. In this cohort, there were no associations observed between COPD and any measure of bone mass.

Conclusions
There was no association between lung function and bone mass in this community dwelling cohort after adjustment for body size and other confounders.
1862-3522
115
Dennison, E.M.
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Dhanwal, D.
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Shaheen, S.O.
ae8e3194-c8a7-4f38-a71f-32da3ad0ea21
Azagra, R.
e2cf4127-5c23-4b03-933b-352532be22c0
Reading, I.
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Jameson, K.A.
d5fb142d-06af-456e-9016-17497f94e9f2
Sayer, A.A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Dhanwal, D.
f2b25481-4e2e-40fb-89ac-6b3cd076bd52
Shaheen, S.O.
ae8e3194-c8a7-4f38-a71f-32da3ad0ea21
Azagra, R.
e2cf4127-5c23-4b03-933b-352532be22c0
Reading, I.
6f832276-87b7-4a76-a9ed-b4b3df0a3f66
Jameson, K.A.
d5fb142d-06af-456e-9016-17497f94e9f2
Sayer, A.A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6

Dennison, E.M., Dhanwal, D., Shaheen, S.O., Azagra, R., Reading, I., Jameson, K.A., Sayer, A.A. and Cooper, C. (2013) Is lung function associated with bone mineral density? results from the Hertfordshire Cohort Study. Archives of Osteoporosis, 8 (1-2), 115. (doi:10.1007/s11657-012-0115-y). (PMID:23322029)

Record type: Article

Abstract

Summary
Given limited information available regarding associations between lung function and bone mineral density among healthy subjects, we undertook these analyses in the Hertfordshire Cohort Study. Forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC were not associated with bone mineral density at any site; associations with bone mineral content were removed by adjustment for body size.

Purpose
There is limited information available regarding the association between lung function and bone mineral density among healthy elderly subjects. We addressed this issue in the Hertfordshire Cohort Study.

Methods
From the above cohort, 985 subjects (496 men and 489 women) aged 60–72 years were recruited. All subjects underwent bone density measurements using dual energy X-ray absorptiometry and lung function tests using standardised spirometry. Chronic obstructive pulmonary disease (COPD) was defined as a FEV1/FVC ratio <lower limit of normal, calculated using separate equations for men and women.

Results
Measures of lung function (FEV1, FVC and FEV1/FVC) were not associated with bone mineral density at the lumbar spine, femoral neck and total hip in men or women; associations with bone mineral content and bone area were removed by adjustment for body size and lifestyle confounders. In this cohort, there were no associations observed between COPD and any measure of bone mass.

Conclusions
There was no association between lung function and bone mass in this community dwelling cohort after adjustment for body size and other confounders.

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More information

Published date: January 2013
Organisations: Faculty of Medicine, Primary Care & Population Sciences

Identifiers

Local EPrints ID: 349230
URI: https://eprints.soton.ac.uk/id/eprint/349230
ISSN: 1862-3522
PURE UUID: f20d79fd-5be8-4844-b8e8-169eff0d8bfd
ORCID for E.M. Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for I. Reading: ORCID iD orcid.org/0000-0002-1457-6532
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 26 Feb 2013 16:17
Last modified: 20 Jul 2019 01:17

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Contributors

Author: E.M. Dennison ORCID iD
Author: D. Dhanwal
Author: S.O. Shaheen
Author: R. Azagra
Author: I. Reading ORCID iD
Author: K.A. Jameson
Author: A.A. Sayer
Author: C. Cooper ORCID iD

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