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Tissue factor and tissue factor pathway inhibitor: a potential role in pregnancy and obstetric vascular complications?

Tissue factor and tissue factor pathway inhibitor: a potential role in pregnancy and obstetric vascular complications?
Tissue factor and tissue factor pathway inhibitor: a potential role in pregnancy and obstetric vascular complications?
Tissue factor (TF) is the principal cellular initiator of normal blood coagulation. As a result it is considered to be a major regulator of haemostasis and thrombogenesis. In vivo TF activity is regulated by specific circulating inhibitor known as "tissue factor pathway inhibitor (TFPI)". TF is also essential for other cellular processes including embryogenesis and angiogenesis as well as in implantation where it is particularly important in the first trimester. TF is highly expressed in syncytiotrophoblasts (STB) while TFPI is expressed in human umbilical vein endothelial cells (HUVEC). TFPI may be internalized via an endocytic pathway and recycled to the cell surface. The procoagulant tendency of STB may reflect a physiological need for immediate inhibition of hemorrhage in the placental intervillous spaces. Furthermore, the haemostatic balance involving STB and HUVEC may be critical for normal placental function and pregnancy outcome. Homozygous knockouts of both TF and TFPI are generally lethal in fetal mice; heterozygotes survive but with altered coagulation parameters. Despite their apparent association with placental microcirculation-thrombi-formation only few studies have addressed the role of TF and TFPI in the pathogenesis of gestational vascular complications. In this context, detailed studies could provide clinically relevant information.
tissue factor, tissue factor pathway inhibitor, pregnancy, gestational vascular complications
0009-8981
43-46
Dusse, Luci Maria Sant'Ana
038098b2-e713-40dc-9f01-57e6eab075e5
Carvalho, Maria das Graças
d77b0526-befd-4a86-950b-cf14d312fe8c
Cooper, Alan J
0fd55ea3-e62b-4a06-bcc6-332b51cb22e4
Lwaleed, Bashir A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Dusse, Luci Maria Sant'Ana
038098b2-e713-40dc-9f01-57e6eab075e5
Carvalho, Maria das Graças
d77b0526-befd-4a86-950b-cf14d312fe8c
Cooper, Alan J
0fd55ea3-e62b-4a06-bcc6-332b51cb22e4
Lwaleed, Bashir A.
e7c59131-82ad-4a14-a227-7370e91e3f21

Dusse, Luci Maria Sant'Ana, Carvalho, Maria das Graças, Cooper, Alan J and Lwaleed, Bashir A. (2006) Tissue factor and tissue factor pathway inhibitor: a potential role in pregnancy and obstetric vascular complications? Clinica Chimica Acta, 372 (1-2), 43-46. (doi:10.1016/j.cca.2006.03.025). (PMID:16713593)

Record type: Article

Abstract

Tissue factor (TF) is the principal cellular initiator of normal blood coagulation. As a result it is considered to be a major regulator of haemostasis and thrombogenesis. In vivo TF activity is regulated by specific circulating inhibitor known as "tissue factor pathway inhibitor (TFPI)". TF is also essential for other cellular processes including embryogenesis and angiogenesis as well as in implantation where it is particularly important in the first trimester. TF is highly expressed in syncytiotrophoblasts (STB) while TFPI is expressed in human umbilical vein endothelial cells (HUVEC). TFPI may be internalized via an endocytic pathway and recycled to the cell surface. The procoagulant tendency of STB may reflect a physiological need for immediate inhibition of hemorrhage in the placental intervillous spaces. Furthermore, the haemostatic balance involving STB and HUVEC may be critical for normal placental function and pregnancy outcome. Homozygous knockouts of both TF and TFPI are generally lethal in fetal mice; heterozygotes survive but with altered coagulation parameters. Despite their apparent association with placental microcirculation-thrombi-formation only few studies have addressed the role of TF and TFPI in the pathogenesis of gestational vascular complications. In this context, detailed studies could provide clinically relevant information.

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More information

e-pub ahead of print date: 19 May 2006
Published date: October 2006
Keywords: tissue factor, tissue factor pathway inhibitor, pregnancy, gestational vascular complications
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 349252
URI: http://eprints.soton.ac.uk/id/eprint/349252
ISSN: 0009-8981
PURE UUID: 8239f2f0-b639-41cc-8e75-8ed2743ddc3d

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Date deposited: 26 Feb 2013 16:39
Last modified: 16 Jul 2019 21:42

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