Urinary tissue factor: a potential marker of disease
Urinary tissue factor: a potential marker of disease
Tissue factor (TF) is the main physiological initiator of blood coagulation and may be important in the biology of a variety of solid malignancies, particularly where angiogenesis is a critical factor. TF is frequently encrypted in the plasma membrane of cells in contact with blood, and is exposed only after stimulation by certain agonists. Cancer cells variably express TF and cancer cell lines which exhibit multidrug resistance contain more TF than parental cells. TF is increased in both tumour-associated macrophages and blood monocytes and has been implicated in abnormal coagulation activation seen in patients with inflammatory conditions and cancer. TF is also found in urine (uTF) in a lipid-associated form, probably of kidney origin. uTF levels can be assayed in a cost-effective manner and may be clinically important, particularly in patients with renal disorders and malignancy. uTF levels are not significantly affected by age, gender or cigarette smoking.
tissue factor, tumour biology, urinary tissue factor, source and origin, renal disorders, cancer
3-8
Lwaleed, B.A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Bass, P.S.
8498593e-3539-4908-80da-e2606153869a
Francis, J.L.
54a1f2e1-fd7a-4592-b55c-3c856810b68d
3 May 1999
Lwaleed, B.A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Bass, P.S.
8498593e-3539-4908-80da-e2606153869a
Francis, J.L.
54a1f2e1-fd7a-4592-b55c-3c856810b68d
Abstract
Tissue factor (TF) is the main physiological initiator of blood coagulation and may be important in the biology of a variety of solid malignancies, particularly where angiogenesis is a critical factor. TF is frequently encrypted in the plasma membrane of cells in contact with blood, and is exposed only after stimulation by certain agonists. Cancer cells variably express TF and cancer cell lines which exhibit multidrug resistance contain more TF than parental cells. TF is increased in both tumour-associated macrophages and blood monocytes and has been implicated in abnormal coagulation activation seen in patients with inflammatory conditions and cancer. TF is also found in urine (uTF) in a lipid-associated form, probably of kidney origin. uTF levels can be assayed in a cost-effective manner and may be clinically important, particularly in patients with renal disorders and malignancy. uTF levels are not significantly affected by age, gender or cigarette smoking.
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Published date: 3 May 1999
Keywords:
tissue factor, tumour biology, urinary tissue factor, source and origin, renal disorders, cancer
Organisations:
Faculty of Health Sciences
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Local EPrints ID: 349268
URI: http://eprints.soton.ac.uk/id/eprint/349268
PURE UUID: 383212e8-4520-40e0-9d24-77f24f0ff317
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Date deposited: 27 Feb 2013 12:29
Last modified: 06 Aug 2024 01:39
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Author:
P.S. Bass
Author:
J.L. Francis
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