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The significance of measuring monocyte tissue factor activity in patients with breast and colorectal cancer

The significance of measuring monocyte tissue factor activity in patients with breast and colorectal cancer
The significance of measuring monocyte tissue factor activity in patients with breast and colorectal cancer
Monocytes express tissue factor (mTF) in several conditions including cancer where levels may be valuable in assessing tumour presence and progression. Using a two-stage kinetic chromogenic assay (KCA), mTF levels were measured in controls [normal subjects (n = 60) and patients undergoing hernia repair or cholecystectomy (n = 60)], in patients with benign and malignant disease of the breast (n = 83) and of the large bowel (n = 62). This was performed under fresh (resting) conditions and after incubation for 6 h without (unstimulated) and with (stimulated) Escherichia coli endotoxin. The malignant groups showed higher mTF levels than each of the three controls for resting (P < 0.05 breast, P < 0.05 colorectal) unstimulated (P < 0.05 breast, P < 0.05 colorectal) and stimulated cells (P < 0.001 breast, P < 0.01 colorectal). Similarly, the benign inflammatory groups had higher mTF levels than controls for resting (P < 0.05 colorectal), unstimulated (P < 0.05 colorectal) and stimulated cells (P < 0.01 breast, P < 0.01 colorectal). There was no significant difference between malignant and benign inflammatory groups in each organ. mTF levels showed an increase corresponding to that of histological tumour progression and were higher in non-surviving patients. In conclusion, mTF levels are raised in malignant and inflammatory disease compared to controls and patients with non-inflammatory conditions. Stimulated cells give better discrimination between the groups and may be of value in identifying high risk individuals. mTF levels showed an association with tumour grade or stage and the patients' survival time.
monocyte tissue factor, coagulopathy, cancer
0007-0920
279-285
Lwaleed, B.A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Chisholm, M.
c45aab85-a073-4041-9d3f-f7cd738aae4f
Francis, J.L.
54a1f2e1-fd7a-4592-b55c-3c856810b68d
Lwaleed, B.A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Chisholm, M.
c45aab85-a073-4041-9d3f-f7cd738aae4f
Francis, J.L.
54a1f2e1-fd7a-4592-b55c-3c856810b68d

Lwaleed, B.A., Chisholm, M. and Francis, J.L. (1999) The significance of measuring monocyte tissue factor activity in patients with breast and colorectal cancer. British Journal of Cancer, 80 (1-2), 279-285. (doi:10.1038/sj.bjc.6690352). (PMID:10390009)

Record type: Article

Abstract

Monocytes express tissue factor (mTF) in several conditions including cancer where levels may be valuable in assessing tumour presence and progression. Using a two-stage kinetic chromogenic assay (KCA), mTF levels were measured in controls [normal subjects (n = 60) and patients undergoing hernia repair or cholecystectomy (n = 60)], in patients with benign and malignant disease of the breast (n = 83) and of the large bowel (n = 62). This was performed under fresh (resting) conditions and after incubation for 6 h without (unstimulated) and with (stimulated) Escherichia coli endotoxin. The malignant groups showed higher mTF levels than each of the three controls for resting (P < 0.05 breast, P < 0.05 colorectal) unstimulated (P < 0.05 breast, P < 0.05 colorectal) and stimulated cells (P < 0.001 breast, P < 0.01 colorectal). Similarly, the benign inflammatory groups had higher mTF levels than controls for resting (P < 0.05 colorectal), unstimulated (P < 0.05 colorectal) and stimulated cells (P < 0.01 breast, P < 0.01 colorectal). There was no significant difference between malignant and benign inflammatory groups in each organ. mTF levels showed an increase corresponding to that of histological tumour progression and were higher in non-surviving patients. In conclusion, mTF levels are raised in malignant and inflammatory disease compared to controls and patients with non-inflammatory conditions. Stimulated cells give better discrimination between the groups and may be of value in identifying high risk individuals. mTF levels showed an association with tumour grade or stage and the patients' survival time.

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More information

Published date: April 1999
Keywords: monocyte tissue factor, coagulopathy, cancer
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 349272
URI: http://eprints.soton.ac.uk/id/eprint/349272
ISSN: 0007-0920
PURE UUID: cc9335bb-159d-483a-9273-01323140fbb5

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Date deposited: 27 Feb 2013 14:27
Last modified: 16 Jul 2019 21:42

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