Embryonic and induced pluripotent stem cells: understanding, creating, and exploiting the nano-niche for regenerative medicine.
Embryonic and induced pluripotent stem cells: understanding, creating, and exploiting the nano-niche for regenerative medicine.
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have the capacity to differentiate into any specialized cell type of the human body, and therefore, ESC/iPSC-derived cell types offer great potential for regenerative medicine. However, key to realizing this potential requires a strong understanding of stem cell biology, techniques to maintain stem cells, and strategies to manipulate cells to efficiently direct cell differentiation toward a desired cell type. As nanoscale science and engineering continues to produce novel nanotechnology platforms, which inform, infiltrate, and impinge on many aspects of everyday life, it is no surprise that stem cell research is turning toward developments in nanotechnology to answer research questions and to overcome obstacles in regenerative medicine. Here we discuss recent advances in ESC and iPSC manipulation using nanomaterials and highlight future challenges within this area of research.
embryonic stem cells, nanomaterials, nanoparticles, naotopography, regenerative medicine, niche
Kingham, Emma Jayne
05ad1291-8428-411a-9202-2577e7ff555c
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
15 February 2013
Kingham, Emma Jayne
05ad1291-8428-411a-9202-2577e7ff555c
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Kingham, Emma Jayne and Oreffo, Richard O.C.
(2013)
Embryonic and induced pluripotent stem cells: understanding, creating, and exploiting the nano-niche for regenerative medicine.
ACS Nano.
(doi:10.1021/nn3037094).
(PMID:23414366)
Abstract
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have the capacity to differentiate into any specialized cell type of the human body, and therefore, ESC/iPSC-derived cell types offer great potential for regenerative medicine. However, key to realizing this potential requires a strong understanding of stem cell biology, techniques to maintain stem cells, and strategies to manipulate cells to efficiently direct cell differentiation toward a desired cell type. As nanoscale science and engineering continues to produce novel nanotechnology platforms, which inform, infiltrate, and impinge on many aspects of everyday life, it is no surprise that stem cell research is turning toward developments in nanotechnology to answer research questions and to overcome obstacles in regenerative medicine. Here we discuss recent advances in ESC and iPSC manipulation using nanomaterials and highlight future challenges within this area of research.
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nn3037094
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Published date: 15 February 2013
Keywords:
embryonic stem cells, nanomaterials, nanoparticles, naotopography, regenerative medicine, niche
Organisations:
Human Development & Health
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Local EPrints ID: 349339
URI: http://eprints.soton.ac.uk/id/eprint/349339
ISSN: 1936-0851
PURE UUID: 5fa10b72-426b-4a49-bc0d-e2313a916f55
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Date deposited: 04 Mar 2013 10:12
Last modified: 15 Mar 2024 03:04
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Author:
Emma Jayne Kingham
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