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Fine-tuning MAPK signaling in the brain: the role of MKP-1

Fine-tuning MAPK signaling in the brain: the role of MKP-1
Fine-tuning MAPK signaling in the brain: the role of MKP-1
Mitogen-activated protein kinase (MAPK) signaling influences a variety of neuronal properties, including structural characteristics such as spine density, and physiological features like long-term potentiation. Spatiotemporal control of MAPK signaling is crucial to generate specific changes in neuronal physiology. However, while many studies have concentrated on the activation of MAPK signaling by trophic factors such as BDNF and neuronal activity, the mechanisms that lead to its termination have not been well described. Two recent reports begin to address this question by focusing on the role of the MAPK phosphatase, MKP-1, in neuronal function. The first study provides a cellular mechanism underlying MKP-1 action in the brain. The second study describes potential roles of MKP-1 during stress and major depression.
1942-0889
281-283
Jeanneteau, Freddy
7da61a32-2f42-425d-a988-a7395e01a4cb
Deinhardt, Katrin
5f4fe23b-2317-499f-ba6d-e639a4885dc1
Jeanneteau, Freddy
7da61a32-2f42-425d-a988-a7395e01a4cb
Deinhardt, Katrin
5f4fe23b-2317-499f-ba6d-e639a4885dc1

Jeanneteau, Freddy and Deinhardt, Katrin (2011) Fine-tuning MAPK signaling in the brain: the role of MKP-1. Communicative & Integrative Biology, 4 (3), 281-283. (doi:10.4161/cib.4.3.14766). (PMID:21980558)

Record type: Article

Abstract

Mitogen-activated protein kinase (MAPK) signaling influences a variety of neuronal properties, including structural characteristics such as spine density, and physiological features like long-term potentiation. Spatiotemporal control of MAPK signaling is crucial to generate specific changes in neuronal physiology. However, while many studies have concentrated on the activation of MAPK signaling by trophic factors such as BDNF and neuronal activity, the mechanisms that lead to its termination have not been well described. Two recent reports begin to address this question by focusing on the role of the MAPK phosphatase, MKP-1, in neuronal function. The first study provides a cellular mechanism underlying MKP-1 action in the brain. The second study describes potential roles of MKP-1 during stress and major depression.

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Published date: May 2011
Organisations: Centre for Biological Sciences

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Local EPrints ID: 349472
URI: http://eprints.soton.ac.uk/id/eprint/349472
ISSN: 1942-0889
PURE UUID: cea99e8d-3eec-4c12-a7ca-d8f158b557c8
ORCID for Katrin Deinhardt: ORCID iD orcid.org/0000-0002-6473-5298

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Date deposited: 05 Mar 2013 16:05
Last modified: 07 Jul 2020 00:33

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Contributors

Author: Freddy Jeanneteau

University divisions

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