Predicting local cell deformations in engineered tissue constructs: a multilevel finite element approach
Predicting local cell deformations in engineered tissue constructs: a multilevel finite element approach
A multilevel finite element approach is applied to predict local cell deformations in engineered tissue constructs. Cell deformations are predicted from detailed nonlinear FE analysis of the microstructure, consisting of an arrangement of cells embedded in matrix material. Effective macroscopic tissue behavior is derived by a computational homogenization procedure. To illustrate this approach, we simulated the compression of a skeletal muscle tissue construct and studied the influence of microstructural heterogeneity on local cell deformations. Results show that heterogeneity has a profound impact on local cell deformations, which highly exceed macroscopic deformations. Moreover, microstructural heterogeneity and the presence of neighboring cells leads to complex cell shapes and causes non-uniform deformations within a cell.
198-207
Breuls, Roel G.M.
914914bc-cc13-48aa-bbe0-c9056ecf493e
Sengers, Bram G.
d6b771b1-4ede-48c5-9644-fa86503941aa
Oomens, Cees W.J.
e8a85b85-3719-4909-9f82-4f03d8a43263
Bouten, Carlijn V.C.
170ccec4-ebe3-4a3f-b21e-29a5ff285af3
Baaijens, Frank P.T.
bc1973f5-8094-41d1-a218-f3a3e1e1b670
29 March 2002
Breuls, Roel G.M.
914914bc-cc13-48aa-bbe0-c9056ecf493e
Sengers, Bram G.
d6b771b1-4ede-48c5-9644-fa86503941aa
Oomens, Cees W.J.
e8a85b85-3719-4909-9f82-4f03d8a43263
Bouten, Carlijn V.C.
170ccec4-ebe3-4a3f-b21e-29a5ff285af3
Baaijens, Frank P.T.
bc1973f5-8094-41d1-a218-f3a3e1e1b670
Breuls, Roel G.M., Sengers, Bram G., Oomens, Cees W.J., Bouten, Carlijn V.C. and Baaijens, Frank P.T.
(2002)
Predicting local cell deformations in engineered tissue constructs: a multilevel finite element approach.
Journal of Biomechanical Engineering, 124 (2), .
(doi:10.1115/1.1449492).
(PMID:12002129)
Abstract
A multilevel finite element approach is applied to predict local cell deformations in engineered tissue constructs. Cell deformations are predicted from detailed nonlinear FE analysis of the microstructure, consisting of an arrangement of cells embedded in matrix material. Effective macroscopic tissue behavior is derived by a computational homogenization procedure. To illustrate this approach, we simulated the compression of a skeletal muscle tissue construct and studied the influence of microstructural heterogeneity on local cell deformations. Results show that heterogeneity has a profound impact on local cell deformations, which highly exceed macroscopic deformations. Moreover, microstructural heterogeneity and the presence of neighboring cells leads to complex cell shapes and causes non-uniform deformations within a cell.
This record has no associated files available for download.
More information
Published date: 29 March 2002
Organisations:
Faculty of Engineering and the Environment
Identifiers
Local EPrints ID: 349741
URI: http://eprints.soton.ac.uk/id/eprint/349741
ISSN: 0148-0731
PURE UUID: f1f80d59-f7fa-467a-b8f6-214b27df94d5
Catalogue record
Date deposited: 12 Mar 2013 14:15
Last modified: 15 Mar 2024 03:26
Export record
Altmetrics
Contributors
Author:
Roel G.M. Breuls
Author:
Cees W.J. Oomens
Author:
Carlijn V.C. Bouten
Author:
Frank P.T. Baaijens
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
