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Predicting local cell deformations in engineered tissue constructs: a multilevel finite element approach

Predicting local cell deformations in engineered tissue constructs: a multilevel finite element approach
Predicting local cell deformations in engineered tissue constructs: a multilevel finite element approach
A multilevel finite element approach is applied to predict local cell deformations in engineered tissue constructs. Cell deformations are predicted from detailed nonlinear FE analysis of the microstructure, consisting of an arrangement of cells embedded in matrix material. Effective macroscopic tissue behavior is derived by a computational homogenization procedure. To illustrate this approach, we simulated the compression of a skeletal muscle tissue construct and studied the influence of microstructural heterogeneity on local cell deformations. Results show that heterogeneity has a profound impact on local cell deformations, which highly exceed macroscopic deformations. Moreover, microstructural heterogeneity and the presence of neighboring cells leads to complex cell shapes and causes non-uniform deformations within a cell.
0148-0731
198-207
Breuls, Roel G.M.
914914bc-cc13-48aa-bbe0-c9056ecf493e
Sengers, Bram G.
d6b771b1-4ede-48c5-9644-fa86503941aa
Oomens, Cees W.J.
e8a85b85-3719-4909-9f82-4f03d8a43263
Bouten, Carlijn V.C.
170ccec4-ebe3-4a3f-b21e-29a5ff285af3
Baaijens, Frank P.T.
bc1973f5-8094-41d1-a218-f3a3e1e1b670
Breuls, Roel G.M.
914914bc-cc13-48aa-bbe0-c9056ecf493e
Sengers, Bram G.
d6b771b1-4ede-48c5-9644-fa86503941aa
Oomens, Cees W.J.
e8a85b85-3719-4909-9f82-4f03d8a43263
Bouten, Carlijn V.C.
170ccec4-ebe3-4a3f-b21e-29a5ff285af3
Baaijens, Frank P.T.
bc1973f5-8094-41d1-a218-f3a3e1e1b670

Breuls, Roel G.M., Sengers, Bram G., Oomens, Cees W.J., Bouten, Carlijn V.C. and Baaijens, Frank P.T. (2002) Predicting local cell deformations in engineered tissue constructs: a multilevel finite element approach. Journal of Biomechanical Engineering, 124 (2), 198-207. (doi:10.1115/1.1449492). (PMID:12002129)

Record type: Article

Abstract

A multilevel finite element approach is applied to predict local cell deformations in engineered tissue constructs. Cell deformations are predicted from detailed nonlinear FE analysis of the microstructure, consisting of an arrangement of cells embedded in matrix material. Effective macroscopic tissue behavior is derived by a computational homogenization procedure. To illustrate this approach, we simulated the compression of a skeletal muscle tissue construct and studied the influence of microstructural heterogeneity on local cell deformations. Results show that heterogeneity has a profound impact on local cell deformations, which highly exceed macroscopic deformations. Moreover, microstructural heterogeneity and the presence of neighboring cells leads to complex cell shapes and causes non-uniform deformations within a cell.

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Published date: 29 March 2002
Organisations: Faculty of Engineering and the Environment

Identifiers

Local EPrints ID: 349741
URI: http://eprints.soton.ac.uk/id/eprint/349741
ISSN: 0148-0731
PURE UUID: f1f80d59-f7fa-467a-b8f6-214b27df94d5
ORCID for Bram G. Sengers: ORCID iD orcid.org/0000-0001-5859-6984

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Date deposited: 12 Mar 2013 14:15
Last modified: 10 Dec 2019 01:43

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Contributors

Author: Roel G.M. Breuls
Author: Bram G. Sengers ORCID iD
Author: Cees W.J. Oomens
Author: Carlijn V.C. Bouten
Author: Frank P.T. Baaijens

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