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The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)

The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)
The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)
The human MAP kinase-interacting kinases (or MAP kinase signal-integrating kinases), Mnks, comprise a group of four proteins derived from two genes (Gene symbols: MKNK1 and MKNK2) by alternative splicing. Mnk1a/b differ at their C-termini, as do Mnk2a/2b: in each case, the a-form possesses a longer C-terminal region than the b-form, which lacks the MAP kinase-binding region. The N-termini of all forms contain a polybasic region which binds importin a and the translation factor scaffold protein eukaryotic initiation factor (eIF) 4G. The catalytic domains of Mnk1a/b and Mnk2a/b share three unusual features: two short inserts and a DFD feature where other kinases have DFG. Mnk isoforms differ markedly in their activity and regulation, and in subcellular localization. The best-characterised Mnk substrate is eIF4E. The cellular role of eIF4E phosphorylation remains unclear: it may promote export of certain mRNAs from the nucleus. Other Mnk substrates bind to AU-rich elements that modulate the stability/translation of specific mRNAs. Mnks may also control production of inflammatory mediators and signaling from tyrosine kinase receptors, as well as cell proliferation or survival.
1093-9946
5359-5373
Buxade, Maria
eaee4453-8bfc-492d-9636-f136f77a5912
Parra-Palau, Josep L.
1d47408d-4707-434c-b54a-7a5d55db3d43
Proud, Christopher G.
59dabfc8-4b44-4be8-a17f-578a58550cb3
Buxade, Maria
eaee4453-8bfc-492d-9636-f136f77a5912
Parra-Palau, Josep L.
1d47408d-4707-434c-b54a-7a5d55db3d43
Proud, Christopher G.
59dabfc8-4b44-4be8-a17f-578a58550cb3

Buxade, Maria, Parra-Palau, Josep L. and Proud, Christopher G. (2008) The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases). Frontiers in Bioscience, (13), 5359-5373. (doi:10.2741/3086). (PMID:18508592)

Record type: Article

Abstract

The human MAP kinase-interacting kinases (or MAP kinase signal-integrating kinases), Mnks, comprise a group of four proteins derived from two genes (Gene symbols: MKNK1 and MKNK2) by alternative splicing. Mnk1a/b differ at their C-termini, as do Mnk2a/2b: in each case, the a-form possesses a longer C-terminal region than the b-form, which lacks the MAP kinase-binding region. The N-termini of all forms contain a polybasic region which binds importin a and the translation factor scaffold protein eukaryotic initiation factor (eIF) 4G. The catalytic domains of Mnk1a/b and Mnk2a/b share three unusual features: two short inserts and a DFD feature where other kinases have DFG. Mnk isoforms differ markedly in their activity and regulation, and in subcellular localization. The best-characterised Mnk substrate is eIF4E. The cellular role of eIF4E phosphorylation remains unclear: it may promote export of certain mRNAs from the nucleus. Other Mnk substrates bind to AU-rich elements that modulate the stability/translation of specific mRNAs. Mnks may also control production of inflammatory mediators and signaling from tyrosine kinase receptors, as well as cell proliferation or survival.

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More information

Published date: 1 May 2008
Organisations: Centre for Biological Sciences

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Local EPrints ID: 350172
URI: https://eprints.soton.ac.uk/id/eprint/350172
ISSN: 1093-9946
PURE UUID: c5d22c37-b4f1-4861-a75b-be8443f9b7b5

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Date deposited: 19 Mar 2013 11:00
Last modified: 18 Jul 2017 04:36

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Contributors

Author: Maria Buxade
Author: Josep L. Parra-Palau
Author: Christopher G. Proud

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