The University of Southampton
University of Southampton Institutional Repository

The Young Everest Study: preliminary report of changes in sleep and cerebral blood flow velocity during slow ascent to altitude in unacclimatised children

Gavlak, Johanna C., Stocks, Janet, Laverty, Aidan, Fettes, Emma, Bucks, Romola, Sonnappa, Samatha, Cooper, Janine, Grocott, Michael P., Levett, Denny Z., Martin, Daniel S., Imray, Christopher H. and Kirkham, Fenella J. (2013) The Young Everest Study: preliminary report of changes in sleep and cerebral blood flow velocity during slow ascent to altitude in unacclimatised children Archives of Disease in Childhood, 98, (5), pp. 356-362. (doi:10.1136/archdischild-2012-302512). (PMID:23471157).

Record type: Article

Abstract

BACKGROUND: Cerebral blood flow velocity (CBFV) and sleep physiology in healthy children exposed to hypoxia and hypocarbia are under-researched.

AIM: To investigate associations between sleep variables, daytime end-tidal carbon dioxide (EtCO2) and CBFV in children during high-altitude ascent.

METHODS: Vital signs, overnight cardiorespiratory sleep studies and transcranial Doppler were undertaken in nine children (aged 6-13 years) at low altitude (130 m), and then at moderate (1300 m) and high (3500 m) altitude during a 5-day ascent.

RESULTS: Daytime (130 m: 98%; 3500 m: 90%, p=0.004) and mean (130 m: 97%, 1300 m: 94%, 3500: 87%, p=0.0005) and minimum (130 m: 92%, 1300 m: 84%, 3500 m: 79%, p=0.0005) overnight pulse oximetry oxyhaemoglobin saturation decreased, and the number of central apnoeas increased at altitude (130 m: 0.2/h, 1300 m: 1.2/h, 3500 m: 3.5/h, p=0.2), correlating inversely with EtCO2 (R(2) 130 m: 0.78; 3500 m: 0.45). Periodic breathing occurred for median (IQR) 0.0 (0; 0.3)% (130 m) and 0.2 (0; 1.2)% (3500 m) of total sleep time. At 3500 m compared with 130 m, there were increases in middle (MCA) (mean (SD) left 29.2 (42.3)%, p=0.053; right 9.9 (12)%, p=0.037) and anterior cerebral (ACA) (left 65.2 (69)%, p=0.024; right 109 (179)%; p=0.025) but not posterior or basilar CBFV. The right MCA CBFV increase at 3500 m was predicted by baseline CBFV and change in daytime SpO2 and EtCO2 at 3500 m (R(2) 0.92); these associations were not seen on the left.

CONCLUSIONS: This preliminary report suggests that sleep physiology is disturbed in children even with slow ascent to altitude. The regional variations in CBFV and their association with hypoxia and hypocapnia require further investigation.

PDF __userfiles.soton.ac.uk_Users_nsc_mydesktop_350227kirkham.pdf - Version of Record
Restricted to Repository staff only
Download (233kB)

More information

e-pub ahead of print date: 7 March 2013
Published date: May 2013
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 350227
URI: http://eprints.soton.ac.uk/id/eprint/350227
ISSN: 0003-9888
PURE UUID: 9070fc4e-78b4-4016-ac66-f5435c34e5a9

Catalogue record

Date deposited: 20 Mar 2013 16:22
Last modified: 18 Jul 2017 04:36

Export record

Altmetrics

Contributors

Author: Johanna C. Gavlak
Author: Janet Stocks
Author: Aidan Laverty
Author: Emma Fettes
Author: Romola Bucks
Author: Samatha Sonnappa
Author: Janine Cooper
Author: Denny Z. Levett
Author: Daniel S. Martin
Author: Christopher H. Imray
Author: Fenella J. Kirkham

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×