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The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma

The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma
The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma
A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1 1,661 1 affected individuals, we investigated risk for developing a specific tumor karyotype. The t(1111;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associated with the CCND1 c.870G>A polymorphism (P = 7.96 × 1 10?1111). These results provide a model in which a constitutive genetic factor is associated with risk of a specific chromosomal translocation.
1061-4036
522-525
Weinhold, Niels
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Johnson, David C.
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Chubb, Daniel
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Chen, Bowang
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Försti, Asta
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Hosking, Fay J.
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Broderick, Peter
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Ma, Yussanne P.
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Dobbins, Sara E.
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Hose, Dirk
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Walker, Brian A.
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Davies, Faith E.
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Kaiser, Martin F.
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Li, Ni L.
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Gregory, Walter A.
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Jackson, Graham H.
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Witzens-Harig, Mathias
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Neben, Kai
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Hoffmann, Per
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Nöthen, Markus M.
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Mühleisen, Thomas W.
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Eisele, Lewin
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Ross, Fiona M
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Jauch, Anna
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Goldschmidt, Hartmut
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Houlston, Richard S.
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Morgan, Gareth J.
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Hemminki, Kari
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Weinhold, Niels
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Johnson, David C.
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Chubb, Daniel
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Chen, Bowang
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Försti, Asta
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Hosking, Fay J.
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Broderick, Peter
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Ma, Yussanne P.
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Dobbins, Sara E.
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Hose, Dirk
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Walker, Brian A.
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Davies, Faith E.
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Kaiser, Martin F.
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Li, Ni L.
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Gregory, Walter A.
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Jackson, Graham H.
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Witzens-Harig, Mathias
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Neben, Kai
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Hoffmann, Per
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Nöthen, Markus M.
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Mühleisen, Thomas W.
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Eisele, Lewin
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Ross, Fiona M
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Jauch, Anna
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Goldschmidt, Hartmut
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Houlston, Richard S.
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Morgan, Gareth J.
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Hemminki, Kari
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Weinhold, Niels, Johnson, David C., Chubb, Daniel, Chen, Bowang, Försti, Asta, Hosking, Fay J., Broderick, Peter, Ma, Yussanne P., Dobbins, Sara E., Hose, Dirk, Walker, Brian A., Davies, Faith E., Kaiser, Martin F., Li, Ni L., Gregory, Walter A., Jackson, Graham H., Witzens-Harig, Mathias, Neben, Kai, Hoffmann, Per, Nöthen, Markus M., Mühleisen, Thomas W., Eisele, Lewin, Ross, Fiona M, Jauch, Anna, Goldschmidt, Hartmut, Houlston, Richard S., Morgan, Gareth J. and Hemminki, Kari (2013) The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Nature Genetics, 45 (5), 522-525. (doi:10.1038/ng.2583). (PMID:23502783)

Record type: Article

Abstract

A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1 1,661 1 affected individuals, we investigated risk for developing a specific tumor karyotype. The t(1111;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associated with the CCND1 c.870G>A polymorphism (P = 7.96 × 1 10?1111). These results provide a model in which a constitutive genetic factor is associated with risk of a specific chromosomal translocation.

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e-pub ahead of print date: 17 March 2013
Published date: 26 April 2013
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 350232
URI: http://eprints.soton.ac.uk/id/eprint/350232
ISSN: 1061-4036
PURE UUID: e6586a46-b7ef-445c-8245-3a7931affa90

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Date deposited: 20 Mar 2013 14:35
Last modified: 27 Apr 2022 08:35

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Contributors

Author: Niels Weinhold
Author: David C. Johnson
Author: Daniel Chubb
Author: Bowang Chen
Author: Asta Försti
Author: Fay J. Hosking
Author: Peter Broderick
Author: Yussanne P. Ma
Author: Sara E. Dobbins
Author: Dirk Hose
Author: Brian A. Walker
Author: Faith E. Davies
Author: Martin F. Kaiser
Author: Ni L. Li
Author: Walter A. Gregory
Author: Graham H. Jackson
Author: Mathias Witzens-Harig
Author: Kai Neben
Author: Per Hoffmann
Author: Markus M. Nöthen
Author: Thomas W. Mühleisen
Author: Lewin Eisele
Author: Fiona M Ross
Author: Anna Jauch
Author: Hartmut Goldschmidt
Author: Richard S. Houlston
Author: Gareth J. Morgan
Author: Kari Hemminki

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