mTOR Signalling in Health and Disease
mTOR Signalling in Health and Disease
The TOR (target of rapamycin) proteins are found in all eukaryotes. TOR has a protein kinase domain, as well as other domains through which it interacts with partner proteins to form at least two types of multiprotein complex, TORC1 and TORC2 (TOR complexes 1 and 2). Rapamycin, an antibiotic and immunosuppressant, inhibits functions of TORC1. Use of this drug has revealed roles for TORC1 and its mammalian counterpart, mTORC1, in promoting many anabolic processes. mTORC1 signalling is activated by growth factors and nutrients. It is highly active in many cancers and plays a role in tumorigenesis and in other diseases. Much less is known so far about the functions and regulation of (m)TORC2. The goal of this meeting was to bring together researchers studying the roles of mTORC1/2 in normal cell and animal physiology in diverse systems, as well as scientists exploring the therapeutic value of inhibiting mTOR (mammalian TOR) signalling.
mammalian target of rapamycin (mtor), protein kinase, rapamycin, signalling, target of rapamycin (tor), target of rapamycin complex (torc)
431-436
Proud, Christopher G.
59dabfc8-4b44-4be8-a17f-578a58550cb3
April 2011
Proud, Christopher G.
59dabfc8-4b44-4be8-a17f-578a58550cb3
Abstract
The TOR (target of rapamycin) proteins are found in all eukaryotes. TOR has a protein kinase domain, as well as other domains through which it interacts with partner proteins to form at least two types of multiprotein complex, TORC1 and TORC2 (TOR complexes 1 and 2). Rapamycin, an antibiotic and immunosuppressant, inhibits functions of TORC1. Use of this drug has revealed roles for TORC1 and its mammalian counterpart, mTORC1, in promoting many anabolic processes. mTORC1 signalling is activated by growth factors and nutrients. It is highly active in many cancers and plays a role in tumorigenesis and in other diseases. Much less is known so far about the functions and regulation of (m)TORC2. The goal of this meeting was to bring together researchers studying the roles of mTORC1/2 in normal cell and animal physiology in diverse systems, as well as scientists exploring the therapeutic value of inhibiting mTOR (mammalian TOR) signalling.
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Published date: April 2011
Keywords:
mammalian target of rapamycin (mtor), protein kinase, rapamycin, signalling, target of rapamycin (tor), target of rapamycin complex (torc)
Organisations:
Centre for Biological Sciences
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Local EPrints ID: 350250
URI: http://eprints.soton.ac.uk/id/eprint/350250
ISSN: 0300-5127
PURE UUID: 9d811f6c-3edc-4d5f-a8fe-161c8a7734ef
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Date deposited: 20 Mar 2013 12:43
Last modified: 14 Mar 2024 13:23
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Author:
Christopher G. Proud
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