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Highly sensitive biosensor based on UV-imprinted layered polymeric-inorganic composite waveguides

Highly sensitive biosensor based on UV-imprinted layered polymeric-inorganic composite waveguides
Highly sensitive biosensor based on UV-imprinted layered polymeric-inorganic composite waveguides
An evanescent field sensor utilizing layered polymeric-inorganic composite waveguide configuration was developed in this work. The composite waveguide structure consists of a UV-imprint patterned polymer inverted rib waveguide with a Ta2O5 thin film sputter-deposited on top of the low refractive index polymer layers. The results suggest that the polymer based sensor can achieve a detection limit of 3 × 10(-7) RIU for refractive index sensing and corresponding limit of about 100 fg/mm2 for molecular adsorption detection. Besides enhancing the sensitivity significantly, the inorganic coating on the polymer layer was found to block water absorption effectively into the waveguide resulting in a stabilized sensor operation. The ability to use the developed sensor in specific molecular detection was confirmed by investigating antibody - antigen binding reactions. The results of this work demonstrate that high performance sensing capability can be obtained with the developed composite waveguide sensor.
1094-4087
20309-20317
Wang, M.
66a75e8c-a780-4fe8-8aa6-b37e80a6c134
Hiltunen, J.
cf4de971-1190-45ee-8809-c31cb8b4b8f4
Liebert, C.
5de8b0f3-88e5-488c-9d36-152b8b21d0d1
Pearce, S.
54891fdd-25ca-4768-ab4d-27f51be1e3e9
Charlton, Martin
fcf86ab0-8f34-411a-b576-4f684e51e274
Hakalahtim, L.
97cabc1a-5c3a-49cd-9967-49e0df0071b7
Karioja, P.
5e3e7ea3-7c69-40a8-afa5-fe1895716a9e
Myllyla, R.
508262e0-08b0-4dd7-8202-99effe8952e9
Wang, M.
66a75e8c-a780-4fe8-8aa6-b37e80a6c134
Hiltunen, J.
cf4de971-1190-45ee-8809-c31cb8b4b8f4
Liebert, C.
5de8b0f3-88e5-488c-9d36-152b8b21d0d1
Pearce, S.
54891fdd-25ca-4768-ab4d-27f51be1e3e9
Charlton, Martin
fcf86ab0-8f34-411a-b576-4f684e51e274
Hakalahtim, L.
97cabc1a-5c3a-49cd-9967-49e0df0071b7
Karioja, P.
5e3e7ea3-7c69-40a8-afa5-fe1895716a9e
Myllyla, R.
508262e0-08b0-4dd7-8202-99effe8952e9

Wang, M., Hiltunen, J., Liebert, C., Pearce, S., Charlton, Martin, Hakalahtim, L., Karioja, P. and Myllyla, R. (2012) Highly sensitive biosensor based on UV-imprinted layered polymeric-inorganic composite waveguides. Optics Express, 20 (18), 20309-20317. (doi:10.1364/OE.20.020309).

Record type: Article

Abstract

An evanescent field sensor utilizing layered polymeric-inorganic composite waveguide configuration was developed in this work. The composite waveguide structure consists of a UV-imprint patterned polymer inverted rib waveguide with a Ta2O5 thin film sputter-deposited on top of the low refractive index polymer layers. The results suggest that the polymer based sensor can achieve a detection limit of 3 × 10(-7) RIU for refractive index sensing and corresponding limit of about 100 fg/mm2 for molecular adsorption detection. Besides enhancing the sensitivity significantly, the inorganic coating on the polymer layer was found to block water absorption effectively into the waveguide resulting in a stabilized sensor operation. The ability to use the developed sensor in specific molecular detection was confirmed by investigating antibody - antigen binding reactions. The results of this work demonstrate that high performance sensing capability can be obtained with the developed composite waveguide sensor.

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Published date: 2012
Organisations: Nanoelectronics and Nanotechnology

Identifiers

Local EPrints ID: 350297
URI: https://eprints.soton.ac.uk/id/eprint/350297
ISSN: 1094-4087
PURE UUID: b4cf9bff-530d-485e-99e3-4abb871fb9ba

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Date deposited: 25 Mar 2013 11:32
Last modified: 16 Jul 2019 21:39

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Contributors

Author: M. Wang
Author: J. Hiltunen
Author: C. Liebert
Author: S. Pearce
Author: Martin Charlton
Author: L. Hakalahtim
Author: P. Karioja
Author: R. Myllyla

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