Population differences in immune responses to Bacille Calmette-Guérin vaccination in infancy
Population differences in immune responses to Bacille Calmette-Guérin vaccination in infancy
Bacille Calmette-Guérin (BCG) vaccination induces a marked increase in the interferon (IFN)-gamma response to Mycobacterium tuberculosis purified protein derivative (Mtb PPD) in UK adolescents, but not in Malawian adolescents. We hypothesized that Mtb PPD-induced IFN-gamma after BCG vaccination would be similar in infants from these 2 countries. Infants were vaccinated with BCG during the first 3-13 weeks of life. Three months after BCG vaccination, 51 (100%) of 51 UK infants had an IFN-gamma response to Mtb PPD, compared to 41 (53%) of 78 of Malawian infants, in whom responses varied according to their season of birth. We conclude that population differences in immune responses after BCG vaccination are observed among infants, as well as among young adults.
795-800
Lalor, M.K.
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Ben-Smith, A.
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Gorak-Stolinska, P.
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Weir, R.E.
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Floyd, Sian
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Blitz, R.
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Mvula, H.
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Newport, M.J.
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Branson, K.
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McGrath, N.
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Crampin, A.C.
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Fine, P.E.
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Dockrell, H.M.
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15 March 2009
Lalor, M.K.
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Ben-Smith, A.
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Gorak-Stolinska, P.
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Weir, R.E.
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Floyd, Sian
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Blitz, R.
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Mvula, H.
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Newport, M.J.
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Branson, K.
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McGrath, N.
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Crampin, A.C.
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Fine, P.E.
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Dockrell, H.M.
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Lalor, M.K., Ben-Smith, A., Gorak-Stolinska, P., Weir, R.E., Floyd, Sian, Blitz, R., Mvula, H., Newport, M.J., Branson, K., McGrath, N., Crampin, A.C., Fine, P.E. and Dockrell, H.M.
(2009)
Population differences in immune responses to Bacille Calmette-Guérin vaccination in infancy.
The Journal of Infectious Diseases, 199 (6), .
(doi:10.1086/597069).
(PMID:19434928)
Abstract
Bacille Calmette-Guérin (BCG) vaccination induces a marked increase in the interferon (IFN)-gamma response to Mycobacterium tuberculosis purified protein derivative (Mtb PPD) in UK adolescents, but not in Malawian adolescents. We hypothesized that Mtb PPD-induced IFN-gamma after BCG vaccination would be similar in infants from these 2 countries. Infants were vaccinated with BCG during the first 3-13 weeks of life. Three months after BCG vaccination, 51 (100%) of 51 UK infants had an IFN-gamma response to Mtb PPD, compared to 41 (53%) of 78 of Malawian infants, in whom responses varied according to their season of birth. We conclude that population differences in immune responses after BCG vaccination are observed among infants, as well as among young adults.
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Published date: 15 March 2009
Organisations:
Faculty of Health Sciences
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Local EPrints ID: 350343
URI: http://eprints.soton.ac.uk/id/eprint/350343
ISSN: 0022-1899
PURE UUID: a4d8247a-653e-4a78-a3b8-a7cd19c08f4f
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Date deposited: 21 Mar 2013 15:43
Last modified: 15 Mar 2024 03:46
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Contributors
Author:
M.K. Lalor
Author:
A. Ben-Smith
Author:
P. Gorak-Stolinska
Author:
R.E. Weir
Author:
Sian Floyd
Author:
R. Blitz
Author:
H. Mvula
Author:
M.J. Newport
Author:
K. Branson
Author:
A.C. Crampin
Author:
P.E. Fine
Author:
H.M. Dockrell
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