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A novel biomimetic analysis system for quantitative characterisation of sclerosing foams used for the treatment of varicose veins

A novel biomimetic analysis system for quantitative characterisation of sclerosing foams used for the treatment of varicose veins
A novel biomimetic analysis system for quantitative characterisation of sclerosing foams used for the treatment of varicose veins
A novel analysis system for the quantification of sclerosing foam properties under clinically relevant conditions was developed with the purpose of establishing a robust methodology for comparative characterisation of different foam formulations and production strategies. The developed biomimetic-inspired model comprised of 4 or 10 mm inner diameter polytetrafluoroethylene tubing, filled with a blood substitute and fixed to a platform with an adjustable inclination angle. Sclerosing foams were produced by mixing polidocanol with either atmospheric air or 100% CO2, using a double-syringe system method. Individual foams were injected into the tube, while videos were captured simultaneously. Videos were then transferred to an in-house computational foam analysis system (CFAS) which performed a sequence of semi-automated operations, allowing quantitative characterisation of sclerosing foam dynamic behaviour. Using CFAS, degradation rates of different foams were measured and the effect of gas composition, liquid sclerosant concentration and time delay between foam production and injection were evaluated.
0957-4530
1417-1423
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Ankrett, Dyan N.
22d8eb6d-70db-4b47-9587-c4d048cd34b7
O'Byrne, Vincent
f9a573d5-6e2d-4d67-9478-dcfc161d79e6
Willis, Sean
c52887ff-55d1-4910-81db-dd70448db56f
Wright, David
b82e86cd-3f68-4e1e-a140-4cd9a1ed0d42
Lewis, Andrew
8d08a0a8-aba0-4de3-b4b2-b7aeb15b9e04
Hill, Martyn
0cda65c8-a70f-476f-b126-d2c4460a253e
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Ankrett, Dyan N.
22d8eb6d-70db-4b47-9587-c4d048cd34b7
O'Byrne, Vincent
f9a573d5-6e2d-4d67-9478-dcfc161d79e6
Willis, Sean
c52887ff-55d1-4910-81db-dd70448db56f
Wright, David
b82e86cd-3f68-4e1e-a140-4cd9a1ed0d42
Lewis, Andrew
8d08a0a8-aba0-4de3-b4b2-b7aeb15b9e04
Hill, Martyn
0cda65c8-a70f-476f-b126-d2c4460a253e
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1

Carugo, Dario, Ankrett, Dyan N., O'Byrne, Vincent, Willis, Sean, Wright, David, Lewis, Andrew, Hill, Martyn and Zhang, Xunli (2013) A novel biomimetic analysis system for quantitative characterisation of sclerosing foams used for the treatment of varicose veins. Journal of Materials Science: Materials in Medicine, 24 (6), 1417-1423. (doi:10.1007/s10856-013-4913-6). (PMID:23512153)

Record type: Article

Abstract

A novel analysis system for the quantification of sclerosing foam properties under clinically relevant conditions was developed with the purpose of establishing a robust methodology for comparative characterisation of different foam formulations and production strategies. The developed biomimetic-inspired model comprised of 4 or 10 mm inner diameter polytetrafluoroethylene tubing, filled with a blood substitute and fixed to a platform with an adjustable inclination angle. Sclerosing foams were produced by mixing polidocanol with either atmospheric air or 100% CO2, using a double-syringe system method. Individual foams were injected into the tube, while videos were captured simultaneously. Videos were then transferred to an in-house computational foam analysis system (CFAS) which performed a sequence of semi-automated operations, allowing quantitative characterisation of sclerosing foam dynamic behaviour. Using CFAS, degradation rates of different foams were measured and the effect of gas composition, liquid sclerosant concentration and time delay between foam production and injection were evaluated.

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More information

e-pub ahead of print date: 20 March 2013
Published date: June 2013
Organisations: Bioengineering Group, Mechatronics

Identifiers

Local EPrints ID: 350377
URI: https://eprints.soton.ac.uk/id/eprint/350377
ISSN: 0957-4530
PURE UUID: 9d6de45a-d04c-400b-9874-0bb00bfb3141
ORCID for Martyn Hill: ORCID iD orcid.org/0000-0001-6448-9448

Catalogue record

Date deposited: 26 Mar 2013 11:58
Last modified: 15 Aug 2019 00:56

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