The University of Southampton
University of Southampton Institutional Repository

An inventory of European data sources for the long-term safety evaluation of methylphenidate

An inventory of European data sources for the long-term safety evaluation of methylphenidate
An inventory of European data sources for the long-term safety evaluation of methylphenidate
To compile an inventory of European healthcare databases with potential to study long-term effects of methylphenidate (MPH) in patients with attention deficit hyperactivity disorder (ADHD). Potential databases were identified through expert opinion, the website of the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance, and literature search. An online survey was conducted among database providers/coordinators to ascertain the databases’ appropriateness for inclusion into the inventory. It included questions about database characteristics, sample size, availability of information on drug exposure, clinical data and accessibility. Forty-two databases from 11 countries were identified and their coordinators invited to participate; responses were obtained for 22 (52.4%) databases of which 15 record ADHD diagnoses. Eleven had sufficient data on ADHD diagnosis, drug exposure, and at least one type of outcome information (symptoms/clinical events, weight, height, blood pressure, heart rate) to assess MPH safety. These were Aarhus University Prescription Database, Danish National Birth Cohort (Denmark); German Health Interview and Examination Survey for Children and Adolescents; Health Search Database Thales, Italian ADHD Register, Lombardy Region ADHD Database (Italy); Avon Longitudinal Study of Parents and Children, General Practice Research Database, The Health Improvement Network, QResearch (UK) and IMS Disease Analyzer (UK, Germany, France). Of the 20 databases with no responses, information on seven from publications and/or websites was obtained; Pedianet and the Integrated Primary Care Information database were considered suitable. Many European healthcare databases can be used for multinational long-term safety studies of MPH. Methodological research is underway to investigate the feasibility of their pooling and analysis.
database, methylphenidate, attention deficit hyperactivity disorder, adhd, drug safety, paediatric
1018-8827
Murray, Macey L.
6334b00a-895f-4e11-a256-cb1be1a8a440
Insuk, Suppachai
2649fd1d-a2d7-4ed7-9c91-165f748416eb
Banaschewski, Tobias
4627c589-04cc-4f5b-ac2d-05f547f63dfd
Neubert, Antje C.
fba9fbe1-4ca8-49de-bc24-9947c8622268
McCarthy, Suzanne
afd24582-2804-4843-b041-8de6798f241a
Buitelaar, Jan K.
a2e08a14-4de4-419e-9ea8-1e97ebbdddba
Coghill, David
deea8957-fdfc-488a-a3bb-fb9b536c7172
Dittmann, Ralf W.
e2d36a60-d6c5-485d-8ce5-852d5a1b9bfd
Konrad, Kerstin
327d1cf7-6ccd-4f2a-8391-6bbf9e4f6905
Panei, Pietro
66129eeb-bc6a-4a94-9510-c7af0d44492b
Rosenthal, Eric
8dd99f96-b07c-4f50-9bb2-f77daaaa1b87
Sonuga-Barke, Edmund J.S.
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Wong, Ian C. K.
0df5dc60-185a-4509-a45a-619c57ca84b0
Murray, Macey L.
6334b00a-895f-4e11-a256-cb1be1a8a440
Insuk, Suppachai
2649fd1d-a2d7-4ed7-9c91-165f748416eb
Banaschewski, Tobias
4627c589-04cc-4f5b-ac2d-05f547f63dfd
Neubert, Antje C.
fba9fbe1-4ca8-49de-bc24-9947c8622268
McCarthy, Suzanne
afd24582-2804-4843-b041-8de6798f241a
Buitelaar, Jan K.
a2e08a14-4de4-419e-9ea8-1e97ebbdddba
Coghill, David
deea8957-fdfc-488a-a3bb-fb9b536c7172
Dittmann, Ralf W.
e2d36a60-d6c5-485d-8ce5-852d5a1b9bfd
Konrad, Kerstin
327d1cf7-6ccd-4f2a-8391-6bbf9e4f6905
Panei, Pietro
66129eeb-bc6a-4a94-9510-c7af0d44492b
Rosenthal, Eric
8dd99f96-b07c-4f50-9bb2-f77daaaa1b87
Sonuga-Barke, Edmund J.S.
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Wong, Ian C. K.
0df5dc60-185a-4509-a45a-619c57ca84b0

Murray, Macey L., Insuk, Suppachai, Banaschewski, Tobias, Neubert, Antje C., McCarthy, Suzanne, Buitelaar, Jan K., Coghill, David, Dittmann, Ralf W., Konrad, Kerstin, Panei, Pietro, Rosenthal, Eric, Sonuga-Barke, Edmund J.S. and Wong, Ian C. K. (2013) An inventory of European data sources for the long-term safety evaluation of methylphenidate. European Child & Adolescent Psychiatry. (doi:10.1007/s00787-013-0386-x).

Record type: Article

Abstract

To compile an inventory of European healthcare databases with potential to study long-term effects of methylphenidate (MPH) in patients with attention deficit hyperactivity disorder (ADHD). Potential databases were identified through expert opinion, the website of the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance, and literature search. An online survey was conducted among database providers/coordinators to ascertain the databases’ appropriateness for inclusion into the inventory. It included questions about database characteristics, sample size, availability of information on drug exposure, clinical data and accessibility. Forty-two databases from 11 countries were identified and their coordinators invited to participate; responses were obtained for 22 (52.4%) databases of which 15 record ADHD diagnoses. Eleven had sufficient data on ADHD diagnosis, drug exposure, and at least one type of outcome information (symptoms/clinical events, weight, height, blood pressure, heart rate) to assess MPH safety. These were Aarhus University Prescription Database, Danish National Birth Cohort (Denmark); German Health Interview and Examination Survey for Children and Adolescents; Health Search Database Thales, Italian ADHD Register, Lombardy Region ADHD Database (Italy); Avon Longitudinal Study of Parents and Children, General Practice Research Database, The Health Improvement Network, QResearch (UK) and IMS Disease Analyzer (UK, Germany, France). Of the 20 databases with no responses, information on seven from publications and/or websites was obtained; Pedianet and the Integrated Primary Care Information database were considered suitable. Many European healthcare databases can be used for multinational long-term safety studies of MPH. Methodological research is underway to investigate the feasibility of their pooling and analysis.

Full text not available from this repository.

More information

e-pub ahead of print date: March 2013
Keywords: database, methylphenidate, attention deficit hyperactivity disorder, adhd, drug safety, paediatric
Organisations: Clinical Neuroscience

Identifiers

Local EPrints ID: 350393
URI: https://eprints.soton.ac.uk/id/eprint/350393
ISSN: 1018-8827
PURE UUID: e5148674-6309-42be-b0b4-c79ea805f156

Catalogue record

Date deposited: 26 Mar 2013 12:19
Last modified: 16 Jul 2019 21:39

Export record

Altmetrics

Contributors

Author: Macey L. Murray
Author: Suppachai Insuk
Author: Tobias Banaschewski
Author: Antje C. Neubert
Author: Suzanne McCarthy
Author: Jan K. Buitelaar
Author: David Coghill
Author: Ralf W. Dittmann
Author: Kerstin Konrad
Author: Pietro Panei
Author: Eric Rosenthal
Author: Edmund J.S. Sonuga-Barke
Author: Ian C. K. Wong

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×