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Effect of maternal multivitamin supplementation on the mental and psychomotor development of children who are born to HIV-1-infected mothers in Tanzania

Effect of maternal multivitamin supplementation on the mental and psychomotor development of children who are born to HIV-1-infected mothers in Tanzania
Effect of maternal multivitamin supplementation on the mental and psychomotor development of children who are born to HIV-1-infected mothers in Tanzania
OBJECTIVES: To determine the association between maternal multivitamin supplementation and the mental and psychomotor development of children who are born to HIV-1-infected mothers in Tanzania, as secondary endpoints in a randomized trial that investigated the effect of maternal multivitamin supplementation on HIV-1 vertical transmission and progression.

METHODS: The Bayley Scales of Infant Development, 2nd Edition, were administered at 6, 12, and 18 months of age to a subset of children (N = 327). We assessed the effect of vitamin A and multivitamin (vitamins B, C, and E) supplementation using linear regression models and Cox proportional hazard models for the Mental Development Index, the Psychomotor Development Index, and raw scores separately.

RESULTS: Multivitamin supplementation was associated significantly with a mean increase in Psychomotor Development Index score of 2.6 (95% confidence interval: 0.1-5.1). Multivitamins were also significantly protective against the risk for developmental delay on the motor scale (relative risk: 0.4; 95% confidence interval: 0.2-0.7) but not on the Mental Development Index. Vitamin A supplementation had no significant effect on these outcomes.

CONCLUSIONS: Maternal multivitamin supplements provide a low-cost intervention to reduce the risk for developmental delays among infants who are born to HIV-positive mothers in developing countries.
0031-4005
216-225
McGrath, N.
b75c0232-24ec-443f-93a9-69e9e12dc961
Bellinger, D.
4a918ef0-90db-4265-9999-e66a7236223d
Robins, J.
0906d29d-f46f-4d69-b134-f24e55c49997
Msamanga, G.I.
d7825a8c-3340-40e5-aea5-a45dc8acb7ca
Tronick, E.
c152a8cf-1122-403d-b066-11b4ee923d9e
Fawzi, W.W.
57972fc9-8504-42a1-9f9f-094942d11898
McGrath, N.
b75c0232-24ec-443f-93a9-69e9e12dc961
Bellinger, D.
4a918ef0-90db-4265-9999-e66a7236223d
Robins, J.
0906d29d-f46f-4d69-b134-f24e55c49997
Msamanga, G.I.
d7825a8c-3340-40e5-aea5-a45dc8acb7ca
Tronick, E.
c152a8cf-1122-403d-b066-11b4ee923d9e
Fawzi, W.W.
57972fc9-8504-42a1-9f9f-094942d11898

McGrath, N., Bellinger, D., Robins, J., Msamanga, G.I., Tronick, E. and Fawzi, W.W. (2006) Effect of maternal multivitamin supplementation on the mental and psychomotor development of children who are born to HIV-1-infected mothers in Tanzania. Pediatrics, 117 (2), 216-225. (doi:10.1542/peds.2004-1668). (PMID:16452331)

Record type: Article

Abstract

OBJECTIVES: To determine the association between maternal multivitamin supplementation and the mental and psychomotor development of children who are born to HIV-1-infected mothers in Tanzania, as secondary endpoints in a randomized trial that investigated the effect of maternal multivitamin supplementation on HIV-1 vertical transmission and progression.

METHODS: The Bayley Scales of Infant Development, 2nd Edition, were administered at 6, 12, and 18 months of age to a subset of children (N = 327). We assessed the effect of vitamin A and multivitamin (vitamins B, C, and E) supplementation using linear regression models and Cox proportional hazard models for the Mental Development Index, the Psychomotor Development Index, and raw scores separately.

RESULTS: Multivitamin supplementation was associated significantly with a mean increase in Psychomotor Development Index score of 2.6 (95% confidence interval: 0.1-5.1). Multivitamins were also significantly protective against the risk for developmental delay on the motor scale (relative risk: 0.4; 95% confidence interval: 0.2-0.7) but not on the Mental Development Index. Vitamin A supplementation had no significant effect on these outcomes.

CONCLUSIONS: Maternal multivitamin supplements provide a low-cost intervention to reduce the risk for developmental delays among infants who are born to HIV-positive mothers in developing countries.

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e-pub ahead of print date: 1 February 2006
Organisations: Primary Care & Population Sciences, Faculty of Social, Human and Mathematical Sciences

Identifiers

Local EPrints ID: 350534
URI: http://eprints.soton.ac.uk/id/eprint/350534
ISSN: 0031-4005
PURE UUID: fbb02fc4-826c-4754-bc7a-c33f9ba15e4a
ORCID for N. McGrath: ORCID iD orcid.org/0000-0002-1039-0159

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Date deposited: 26 Mar 2013 12:35
Last modified: 29 Oct 2019 01:38

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