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On the definition of a confounder

On the definition of a confounder
On the definition of a confounder
The causal inference literature has provided a clear formal definition of confounding expressed in terms of counterfactual independence. The causal inference literature has not, however, produced a clear formal definition of a confounder, as it has given priority to the concept of confounding over that of a confounder. We consider a number of candidate definitions arising from various more informal statements made in the literature. We consider the properties satisfied by each candidate definition, principally focusing on (i) whether under the candidate definition control for all "confounders" suffices to control for "confounding" and (ii) whether each confounder in some context helps eliminate or reduce confounding bias. Several of the candidate definitions do not have these two properties. Only one candidate definition of those considered satisfies both properties. We propose that a "confounder" be defined as a pre-exposure covariate C for which there exists a set of other covariates X such that effect of the exposure on the outcome is unconfounded conditional on (X,C) but such that for no proper subset of (X,C) is the effect of the exposure on the outcome unconfounded given the subset. A variable that helps reduce bias but not eliminate bias we propose referring to as a "surrogate confounder".
0090-5364
196-220
VanderWeele, Tyler J.
7ba69431-209e-4b4b-919e-aa109daa569d
Shpitser, Ilya
4d295b9b-39e8-417f-b38d-fbb5d7df6992
VanderWeele, Tyler J.
7ba69431-209e-4b4b-919e-aa109daa569d
Shpitser, Ilya
4d295b9b-39e8-417f-b38d-fbb5d7df6992

VanderWeele, Tyler J. and Shpitser, Ilya (2013) On the definition of a confounder. The Annals of Statistics, 41 (1), 196-220. (doi:10.1214/12-AOS1058).

Record type: Article

Abstract

The causal inference literature has provided a clear formal definition of confounding expressed in terms of counterfactual independence. The causal inference literature has not, however, produced a clear formal definition of a confounder, as it has given priority to the concept of confounding over that of a confounder. We consider a number of candidate definitions arising from various more informal statements made in the literature. We consider the properties satisfied by each candidate definition, principally focusing on (i) whether under the candidate definition control for all "confounders" suffices to control for "confounding" and (ii) whether each confounder in some context helps eliminate or reduce confounding bias. Several of the candidate definitions do not have these two properties. Only one candidate definition of those considered satisfies both properties. We propose that a "confounder" be defined as a pre-exposure covariate C for which there exists a set of other covariates X such that effect of the exposure on the outcome is unconfounded conditional on (X,C) but such that for no proper subset of (X,C) is the effect of the exposure on the outcome unconfounded given the subset. A variable that helps reduce bias but not eliminate bias we propose referring to as a "surrogate confounder".

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e-pub ahead of print date: February 2013
Organisations: Statistics

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Local EPrints ID: 350593
URI: http://eprints.soton.ac.uk/id/eprint/350593
ISSN: 0090-5364
PURE UUID: ab8c33c1-83c8-46be-888c-a3201aa0b7f3

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Date deposited: 28 Mar 2013 13:53
Last modified: 14 Mar 2024 13:30

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Author: Tyler J. VanderWeele
Author: Ilya Shpitser

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