Short- and long-term outcomes after laparoscopic and open hepatic resection: systematic review and meta-analysis
Short- and long-term outcomes after laparoscopic and open hepatic resection: systematic review and meta-analysis
BACKGROUND: Laparoscopic liver resection (LLR) is now considered a feasible alternative to open liver resection (OLR) in selected patients. Nevertheless studies comparing LLR and OLR are few and concerns remain about long-term oncological equivalence. The present study compares outcomes with LLR vs. OLR using meta-analytical methods.
METHODS: Electronic literature searches were conducted to identify studies comparing LLR and OLR. Short-term outcomes evaluated included operating time, blood loss, length of hospital stay, peri-operative morbidity and resection margin status. Longer-term outcomes included local and distant recurrence, and overall (OS) and disease-free survival (DFS). Meta-analyses were performed using the Mantel-Haenszel method and Cohen's d method, with results expressed as odds ratio (OR) or standardized mean difference (SMD), respectively, with 95% confidence intervals (CI).
RESULTS: Twenty-six studies met the inclusion criteria with a population of 1678 patients. LLR resulted in longer operating time, but reduced blood loss, portal clamp time, overall and liver-specific complications, ileus and length of stay. No difference was found between LLR and OLR for oncological outcomes.
DISCUSSION: LLR has short-term advantages and seemingly equivalent long-term outcomes and can be considered a feasible alternative to open surgery in experienced hands.
295-308
Mirnezami, Reza
d0d4ded7-1d72-4ce4-9ce1-eac5ded0232f
Mirnezami, Alexander H.
b3c7aee7-46a4-404c-bfe3-f72388e0bc94
Chandrakumaran, Kandiah
f26f4bda-dfcd-439c-b449-3184b7ec7ddb
Abu Hilal, Mohammad
384e1c60-8519-4eed-8e92-91775aad4c47
Pearce, Neil W.
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Primrose, John N.
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Sutcliffe, Robert P.
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1 May 2011
Mirnezami, Reza
d0d4ded7-1d72-4ce4-9ce1-eac5ded0232f
Mirnezami, Alexander H.
b3c7aee7-46a4-404c-bfe3-f72388e0bc94
Chandrakumaran, Kandiah
f26f4bda-dfcd-439c-b449-3184b7ec7ddb
Abu Hilal, Mohammad
384e1c60-8519-4eed-8e92-91775aad4c47
Pearce, Neil W.
6e450393-03db-472b-9231-1aa2e39b0565
Primrose, John N.
d85f3b28-24c6-475f-955b-ec457a3f9185
Sutcliffe, Robert P.
53a0327d-e30f-4bf9-a284-986a82268276
Mirnezami, Reza, Mirnezami, Alexander H., Chandrakumaran, Kandiah, Abu Hilal, Mohammad, Pearce, Neil W., Primrose, John N. and Sutcliffe, Robert P.
(2011)
Short- and long-term outcomes after laparoscopic and open hepatic resection: systematic review and meta-analysis.
HPB, 13 (5), .
(doi:10.1111/j.1477-2574.2011.00295.x).
(PMID:21492329)
Abstract
BACKGROUND: Laparoscopic liver resection (LLR) is now considered a feasible alternative to open liver resection (OLR) in selected patients. Nevertheless studies comparing LLR and OLR are few and concerns remain about long-term oncological equivalence. The present study compares outcomes with LLR vs. OLR using meta-analytical methods.
METHODS: Electronic literature searches were conducted to identify studies comparing LLR and OLR. Short-term outcomes evaluated included operating time, blood loss, length of hospital stay, peri-operative morbidity and resection margin status. Longer-term outcomes included local and distant recurrence, and overall (OS) and disease-free survival (DFS). Meta-analyses were performed using the Mantel-Haenszel method and Cohen's d method, with results expressed as odds ratio (OR) or standardized mean difference (SMD), respectively, with 95% confidence intervals (CI).
RESULTS: Twenty-six studies met the inclusion criteria with a population of 1678 patients. LLR resulted in longer operating time, but reduced blood loss, portal clamp time, overall and liver-specific complications, ileus and length of stay. No difference was found between LLR and OLR for oncological outcomes.
DISCUSSION: LLR has short-term advantages and seemingly equivalent long-term outcomes and can be considered a feasible alternative to open surgery in experienced hands.
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e-pub ahead of print date: 2 March 2011
Published date: 1 May 2011
Organisations:
Cancer Sciences
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Local EPrints ID: 350709
URI: http://eprints.soton.ac.uk/id/eprint/350709
ISSN: 1365-182X
PURE UUID: c9e04963-eff2-4754-bebb-f0f2e3bc9982
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Date deposited: 28 Mar 2013 15:29
Last modified: 15 Mar 2024 02:47
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Author:
Reza Mirnezami
Author:
Kandiah Chandrakumaran
Author:
Mohammad Abu Hilal
Author:
Neil W. Pearce
Author:
Robert P. Sutcliffe
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