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An artificial model for studying fluid dynamics in the obstructed and stented ureter

An artificial model for studying fluid dynamics in the obstructed and stented ureter
An artificial model for studying fluid dynamics in the obstructed and stented ureter
Fluid dynamics in the obstructed and stented ureter represents a non-trivial subject of investigation since, after stent placement, the urine can flow either through the stent lumen or in the extra-luminal space located between the stent wall and the ureteric inner wall. Fluid dynamic investigations can help understanding the phenomena behind stent failure (e.g. stent occlusions due to bacterial colonization and encrustations), which may cause kidney damage due to the associated high pressures generated in the renal pelvis. In this work a microfluidic-based transparent device (ureter model, UM) has been developed to simulate the fluid dynamic environment in a stented ureter. UM geometry has been designed from measurements on pig ureters. Pressure in the renal pelvis compartment has been measured against three variables: fluid viscosity (?), volumetric flow rate (Q) and level of obstruction (OB%). The measurements allowed a quantification of the critical combination of ?, Q and OB% values which may lead to critical pressure levels in the kidney. Moreover, an example showing the possibility of applying particle image velocimetry (PIV) technology to the developed microfluidic device is provided.
Stents, artificial organs, ureter, urodynamics, biomimetic model, kidney stones
5335-5338
IEEE
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
ElMahdy, Motaz
f41a3c77-2929-4467-ae37-5122d22f5c7a
Zhao, Xuefeng
5b7a35ab-f71e-4625-80e2-676c4a15533a
Drake, Marcus
a956bb01-b0d2-4806-ae04-f56c0ab1096a
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Clavica, Francesco
5b484bb7-1299-4c21-a7c8-b216b3d3b2e5
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
ElMahdy, Motaz
f41a3c77-2929-4467-ae37-5122d22f5c7a
Zhao, Xuefeng
5b7a35ab-f71e-4625-80e2-676c4a15533a
Drake, Marcus
a956bb01-b0d2-4806-ae04-f56c0ab1096a
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Clavica, Francesco
5b484bb7-1299-4c21-a7c8-b216b3d3b2e5

Carugo, Dario, ElMahdy, Motaz, Zhao, Xuefeng, Drake, Marcus, Zhang, Xunli and Clavica, Francesco (2013) An artificial model for studying fluid dynamics in the obstructed and stented ureter. In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE. pp. 5335-5338 . (doi:10.1109/EMBC.2013.6610754).

Record type: Conference or Workshop Item (Paper)

Abstract

Fluid dynamics in the obstructed and stented ureter represents a non-trivial subject of investigation since, after stent placement, the urine can flow either through the stent lumen or in the extra-luminal space located between the stent wall and the ureteric inner wall. Fluid dynamic investigations can help understanding the phenomena behind stent failure (e.g. stent occlusions due to bacterial colonization and encrustations), which may cause kidney damage due to the associated high pressures generated in the renal pelvis. In this work a microfluidic-based transparent device (ureter model, UM) has been developed to simulate the fluid dynamic environment in a stented ureter. UM geometry has been designed from measurements on pig ureters. Pressure in the renal pelvis compartment has been measured against three variables: fluid viscosity (?), volumetric flow rate (Q) and level of obstruction (OB%). The measurements allowed a quantification of the critical combination of ?, Q and OB% values which may lead to critical pressure levels in the kidney. Moreover, an example showing the possibility of applying particle image velocimetry (PIV) technology to the developed microfluidic device is provided.

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More information

Published date: July 2013
Venue - Dates: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC’13), Japan, 2013-07-03 - 2013-07-07
Keywords: Stents, artificial organs, ureter, urodynamics, biomimetic model, kidney stones
Organisations: Bioengineering Group

Identifiers

Local EPrints ID: 351040
URI: https://eprints.soton.ac.uk/id/eprint/351040
PURE UUID: d5b9f25d-07cd-4303-b4a4-e75c14e888b7

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Date deposited: 01 May 2013 10:54
Last modified: 13 Mar 2019 18:05

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