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The acute and long-term management of anaphylaxis: protocol for a systematic review

The acute and long-term management of anaphylaxis: protocol for a systematic review
The acute and long-term management of anaphylaxis: protocol for a systematic review
Background:
The European Academy of Allergy and Clinical Immunology is in the process of developing its Guideline for Food Allergy and Anaphylaxis, and this systematic review is one of seven inter-linked evidence syntheses that are being undertaken in order to provide a state-of-the-art synopsis of the current evidence base in relation to epidemiology, prevention, diagnosis and clinical management and impact on quality of life, which will be used to inform clinical recommendations.The aims of this systematic review will be to assess the effectiveness of interventions for the acute management of anaphylaxis, and pharmacological and non-pharmacological approaches for the long-term management of anaphylaxis.

Methods:
A highly sensitive search strategy has been developed, and validated study design filters will be applied to retrieve all articles pertaining to the management of anaphylaxis from electronic bibliographic databases. We will systematically review the literature on the acute management of anaphylaxis by assessing the effectiveness of epinephrine, H1-antihistamines (versus placebo), systemic glucocorticosteroids, methylxanthines or any other treatments for the emergency management of people experiencing anaphylaxis. The main interventions that have been studied in the context of long-term management are anaphylaxis management plans and allergen-specific immunotherapy.

Discussion:
There is at present little in the way of robust evidence to guide decisions on the acute and/or long-term management of anaphylaxis. Given the risk of death and the considerable morbidity associated with anaphylaxis these evidence gaps need to be filled wherever possible; this systematic review will make a start in this area.
anaphylaxis, management, allergy, emergency
14
Dhami, Sangeeta
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Panesar, Sukhmeet S.
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Rader, Tamara
28b4f10b-3aed-46c2-a8bf-8acec33985e3
Muraro, Antonella
c554bef5-502b-4540-a6f0-a3f7c37f0075
Roberts, Graham
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Worm, Margitta
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Sheikh, Aziz
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Dhami, Sangeeta
13edaaf7-b3f8-40f8-be04-834cbe70f0a6
Panesar, Sukhmeet S.
ef7e7e0b-8999-4d52-9b0e-80f08e765725
Rader, Tamara
28b4f10b-3aed-46c2-a8bf-8acec33985e3
Muraro, Antonella
c554bef5-502b-4540-a6f0-a3f7c37f0075
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Worm, Margitta
59406574-ce5f-4ca5-9319-7543c719cc5b
Sheikh, Aziz
5b7eb24b-0820-4bd6-8304-cc46bbe561a8

Dhami, Sangeeta, Panesar, Sukhmeet S., Rader, Tamara, Muraro, Antonella, Roberts, Graham, Worm, Margitta and Sheikh, Aziz (2013) The acute and long-term management of anaphylaxis: protocol for a systematic review. Clinical and Translational Allergy, 3, 14. (doi:10.1186/2045-7022-3-14). (PMID:23575342)

Record type: Article

Abstract

Background:
The European Academy of Allergy and Clinical Immunology is in the process of developing its Guideline for Food Allergy and Anaphylaxis, and this systematic review is one of seven inter-linked evidence syntheses that are being undertaken in order to provide a state-of-the-art synopsis of the current evidence base in relation to epidemiology, prevention, diagnosis and clinical management and impact on quality of life, which will be used to inform clinical recommendations.The aims of this systematic review will be to assess the effectiveness of interventions for the acute management of anaphylaxis, and pharmacological and non-pharmacological approaches for the long-term management of anaphylaxis.

Methods:
A highly sensitive search strategy has been developed, and validated study design filters will be applied to retrieve all articles pertaining to the management of anaphylaxis from electronic bibliographic databases. We will systematically review the literature on the acute management of anaphylaxis by assessing the effectiveness of epinephrine, H1-antihistamines (versus placebo), systemic glucocorticosteroids, methylxanthines or any other treatments for the emergency management of people experiencing anaphylaxis. The main interventions that have been studied in the context of long-term management are anaphylaxis management plans and allergen-specific immunotherapy.

Discussion:
There is at present little in the way of robust evidence to guide decisions on the acute and/or long-term management of anaphylaxis. Given the risk of death and the considerable morbidity associated with anaphylaxis these evidence gaps need to be filled wherever possible; this systematic review will make a start in this area.

Text
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Published date: 10 April 2013
Keywords: anaphylaxis, management, allergy, emergency
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 351083
URI: http://eprints.soton.ac.uk/id/eprint/351083
PURE UUID: ee065577-55a9-49d2-8322-61005eb0f51c
ORCID for Graham Roberts: ORCID iD orcid.org/0000-0003-2252-1248

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Date deposited: 16 Apr 2013 10:48
Last modified: 28 Oct 2023 01:54

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Contributors

Author: Sangeeta Dhami
Author: Sukhmeet S. Panesar
Author: Tamara Rader
Author: Antonella Muraro
Author: Graham Roberts ORCID iD
Author: Margitta Worm
Author: Aziz Sheikh

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