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The acute and long-term management of food allergy: protocol for a rapid systematic review

The acute and long-term management of food allergy: protocol for a rapid systematic review
The acute and long-term management of food allergy: protocol for a rapid systematic review
BACKGROUND: Allergic reactions to plant and animal derived food allergens can have serious consequences for sufferers and their families. The associated social, emotional and financial costs make it a priority to understand the best ways of managing such immune-mediated hypersensitivity responses. Conceptually, there are two main approaches to managing food allergy: those targeting immediate symptoms and those aiming to support long-term management of the condition. The European Academy of Allergy and Clinical Immunology is developing guidelines about what constitutes an effective treatment for food allergies. As part of the guidelines development process, a systematic review is planned to examine published research about the management of food allergy in adults and children.

METHODS: Seven bibliographic databases were searched from their inception to September 30, 2012 for systematic reviews, randomized controlled trials, quasi-randomized controlled trials, controlled clinical trials, controlled before-and-after studies and interrupted time series. Experts were consulted for additional studies. There were no language or geographic restrictions. Studies were critically appraised using the Critical Appraisal Skills Program and Cochrane EPOC Risk of Bias tools. Only studies where people had a diagnosis of food allergy or reported a history of food allergy were included. This means that many studies of conditions that may be caused by food allergy are omitted, because only research in people with an explicit diagnosis or history was eligible.

DISCUSSION: Many initiatives have been tested to treat the immediate symptoms of food allergy (acute management) and to deal with longer lasting symptoms or induce tolerability to potential allergens (long-term management). The best management strategies for people with food allergy are likely to depend on the type of allergy, symptom manifestations and age. There is a real need to increase the amount of high quality research devoted to treatment strategies for food allergy. Food allergy can be debilitating and is affecting an increasing number of children and adults. With such little known about how to effectively manage the condition and its manifestations, this appears a priority for future research.
[12pp.]
de Silva, Debra
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Panesar, Sukhmeet S.
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Thusu, Sundeep
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Rader, Tamara
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Werfel, Thomas
94abe5ac-c6e6-4805-9d07-21c5189b083d
Muraro, Antonella
c554bef5-502b-4540-a6f0-a3f7c37f0075
Hoffmann-Sommergruber, Karin
91f22190-5608-407b-bb3b-63742c1bf524
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Sheikh, Aziz
5b7eb24b-0820-4bd6-8304-cc46bbe561a8
de Silva, Debra
bebaefba-beb5-460f-acbd-9354a549dc9a
Panesar, Sukhmeet S.
ef7e7e0b-8999-4d52-9b0e-80f08e765725
Thusu, Sundeep
bac3dda6-376c-438a-8fd6-957d31e8d1d7
Rader, Tamara
28b4f10b-3aed-46c2-a8bf-8acec33985e3
Werfel, Thomas
94abe5ac-c6e6-4805-9d07-21c5189b083d
Muraro, Antonella
c554bef5-502b-4540-a6f0-a3f7c37f0075
Hoffmann-Sommergruber, Karin
91f22190-5608-407b-bb3b-63742c1bf524
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Sheikh, Aziz
5b7eb24b-0820-4bd6-8304-cc46bbe561a8

de Silva, Debra, Panesar, Sukhmeet S., Thusu, Sundeep, Rader, Tamara, Werfel, Thomas, Muraro, Antonella, Hoffmann-Sommergruber, Karin, Roberts, Graham and Sheikh, Aziz (2013) The acute and long-term management of food allergy: protocol for a rapid systematic review. Clinical and Translational Allergy, 3 (1), [12pp.]. (doi:10.1186/2045-7022-3-12). (PMID:23547741)

Record type: Article

Abstract

BACKGROUND: Allergic reactions to plant and animal derived food allergens can have serious consequences for sufferers and their families. The associated social, emotional and financial costs make it a priority to understand the best ways of managing such immune-mediated hypersensitivity responses. Conceptually, there are two main approaches to managing food allergy: those targeting immediate symptoms and those aiming to support long-term management of the condition. The European Academy of Allergy and Clinical Immunology is developing guidelines about what constitutes an effective treatment for food allergies. As part of the guidelines development process, a systematic review is planned to examine published research about the management of food allergy in adults and children.

METHODS: Seven bibliographic databases were searched from their inception to September 30, 2012 for systematic reviews, randomized controlled trials, quasi-randomized controlled trials, controlled clinical trials, controlled before-and-after studies and interrupted time series. Experts were consulted for additional studies. There were no language or geographic restrictions. Studies were critically appraised using the Critical Appraisal Skills Program and Cochrane EPOC Risk of Bias tools. Only studies where people had a diagnosis of food allergy or reported a history of food allergy were included. This means that many studies of conditions that may be caused by food allergy are omitted, because only research in people with an explicit diagnosis or history was eligible.

DISCUSSION: Many initiatives have been tested to treat the immediate symptoms of food allergy (acute management) and to deal with longer lasting symptoms or induce tolerability to potential allergens (long-term management). The best management strategies for people with food allergy are likely to depend on the type of allergy, symptom manifestations and age. There is a real need to increase the amount of high quality research devoted to treatment strategies for food allergy. Food allergy can be debilitating and is affecting an increasing number of children and adults. With such little known about how to effectively manage the condition and its manifestations, this appears a priority for future research.

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Published date: 30 March 2013
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 351086
URI: http://eprints.soton.ac.uk/id/eprint/351086
PURE UUID: fe9f80fc-15ec-404f-aec1-8c99fde52e7c
ORCID for Graham Roberts: ORCID iD orcid.org/0000-0003-2252-1248

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Date deposited: 16 Apr 2013 11:49
Last modified: 28 Oct 2023 01:54

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Contributors

Author: Debra de Silva
Author: Sukhmeet S. Panesar
Author: Sundeep Thusu
Author: Tamara Rader
Author: Thomas Werfel
Author: Antonella Muraro
Author: Karin Hoffmann-Sommergruber
Author: Graham Roberts ORCID iD
Author: Aziz Sheikh

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