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Uterine secretomics: a window on the maternal-embryo interface

Uterine secretomics: a window on the maternal-embryo interface
Uterine secretomics: a window on the maternal-embryo interface
The analysis of endometrial secretions offers a window on human peri-implantation events that have hitherto been difficult to study noninvasively. Uterine secretomic analysis provides a sensitive means of interrogating the contents of secretions, which have been shown to play a key role in determining endometrial receptivity and embryo-endometrial signaling, and in providing a nourishing environment to the preimplantation embryo. Compared with other means of assessing the endometrium with genomics or proteomics, secretomics offers a nondisruptive approach, allowing analysis during conception cycles. It also provides information on the downstream molecular profile directly encountered by the embryo, offering an integrated review of the complete endometrial surface rather than information representative of only a discrete biopsy site. In this article, recent data derived from uterine secretomics are reviewed. In addition to in vivo studies, recent data from in vitro studies that are changing our understanding of the role of the endometrium in embryo selection are reviewed. Finally, the role of uterine secretions in nutrition and early development programming of the embryo is considered.
0015-0282
1093-1099
Cheong, Ying
4efbba2a-3036-4dce-82f1-8b4017952c83
Boomsma, Carolien
3e14e0d3-fc48-4200-95ed-ada5736987e8
Heijnen, Cobi
87512b41-e6ab-4157-892f-3568e121f9b6
Macklon, Nick
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Cheong, Ying
4efbba2a-3036-4dce-82f1-8b4017952c83
Boomsma, Carolien
3e14e0d3-fc48-4200-95ed-ada5736987e8
Heijnen, Cobi
87512b41-e6ab-4157-892f-3568e121f9b6
Macklon, Nick
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e

Cheong, Ying, Boomsma, Carolien, Heijnen, Cobi and Macklon, Nick (2013) Uterine secretomics: a window on the maternal-embryo interface. Fertility and Sterility, 99 (4), 1093-1099. (doi:10.1016/j.fertnstert.2013.01.144). (PMID:23433513)

Record type: Article

Abstract

The analysis of endometrial secretions offers a window on human peri-implantation events that have hitherto been difficult to study noninvasively. Uterine secretomic analysis provides a sensitive means of interrogating the contents of secretions, which have been shown to play a key role in determining endometrial receptivity and embryo-endometrial signaling, and in providing a nourishing environment to the preimplantation embryo. Compared with other means of assessing the endometrium with genomics or proteomics, secretomics offers a nondisruptive approach, allowing analysis during conception cycles. It also provides information on the downstream molecular profile directly encountered by the embryo, offering an integrated review of the complete endometrial surface rather than information representative of only a discrete biopsy site. In this article, recent data derived from uterine secretomics are reviewed. In addition to in vivo studies, recent data from in vitro studies that are changing our understanding of the role of the endometrium in embryo selection are reviewed. Finally, the role of uterine secretions in nutrition and early development programming of the embryo is considered.

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Published date: March 2013
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 351716
URI: https://eprints.soton.ac.uk/id/eprint/351716
ISSN: 0015-0282
PURE UUID: 1a973b39-56e8-487a-a6fa-7a8526c6c1fc
ORCID for Ying Cheong: ORCID iD orcid.org/0000-0001-7687-4597

Catalogue record

Date deposited: 24 Apr 2013 08:58
Last modified: 20 Jul 2019 00:51

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Contributors

Author: Ying Cheong ORCID iD
Author: Carolien Boomsma
Author: Cobi Heijnen
Author: Nick Macklon

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