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Poor sleep in PCOS; is melatonin the culprit?

Poor sleep in PCOS; is melatonin the culprit?
Poor sleep in PCOS; is melatonin the culprit?
STUDY QUESTION: Are daily cycles in urinary melatonin and oxidative stress marker levels (8-hydroxydeoxyguanosine) altered in PCOS, and is this associated with changes in sleep quality?

SUMMARY ANSWER: There is an association between elevated nighttime melatonin and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels, and poor sleep quality in our PCOS study group.

WHAT IS KNOWN ALREADY: Women with PCOS are known to have poorer sleep. However, there have been few studies examining the possible association between melatonin levels and sleep quality in women with polycystic ovarian syndrome (PCOS).

STUDY DESIGN, SIZE, DURATION: This is a case-control study of PCOS (n = 26) and non-PCOS control (n = 26) subjects recruited from a tertiary gynaecological centre.

PARTICIPANTS/MATERIALS, SETTING, METHODS: The participants were requested to complete sleep questionnaires for a month. In a subgroup from these cohorts (PCOS, n = 15; controls, n = 18), urine samples were also collected at various time points over a 24-h period. In addition, their sleep patterns and lighting environment were monitored for 3 consecutive days and nights using a wrist-mounted Actiwatch device.

MAIN RESULTS AND THE ROLE OF CHANCE: PCOS women had significantly elevated night-time urinary levels of the melatonin metabolite 6-sulfatoxymelatonin (aMT6s) and of 8-OHdG (both at P < 0.05), as well as significantly reduced sleep quality (P < 0.05), compared with the controls.

LIMITATIONS, REASONS FOR CAUTION: Due to the small sample size of the study, further studies will be required to confirm our findings.

WIDER IMPLICATIONS OF THE FINDINGS: Our preliminary work provides a possible new insight into the interactions between melatonin, increased oxidative stress and sleep in women with PCOS.
PCOS, melatonin, ovary, sleep, oxidative stress
1348-1353
Shreeve, N.
d81d52ed-96a8-4d24-8752-965b6bdcc85b
Cagampang, F.
7cf57d52-4a65-4554-8306-ed65226bc50e
Sadek, K.
bd95e801-e73f-4020-abda-bfdbec400df5
Tolhurst, M.
c7ffa3aa-fc04-43fe-ae97-211a558de3fe
Houldey, A.
9dfdc386-4316-4969-9af2-5aeaccfe643a
Hill, C. M.
867cd0a0-dabc-4152-b4bf-8e9fbc0edf8d
Brook, N.
31515604-a860-4662-8f0d-ab77455f2538
Macklon, N.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Cheong, Y.
4efbba2a-3036-4dce-82f1-8b4017952c83
Shreeve, N.
d81d52ed-96a8-4d24-8752-965b6bdcc85b
Cagampang, F.
7cf57d52-4a65-4554-8306-ed65226bc50e
Sadek, K.
bd95e801-e73f-4020-abda-bfdbec400df5
Tolhurst, M.
c7ffa3aa-fc04-43fe-ae97-211a558de3fe
Houldey, A.
9dfdc386-4316-4969-9af2-5aeaccfe643a
Hill, C. M.
867cd0a0-dabc-4152-b4bf-8e9fbc0edf8d
Brook, N.
31515604-a860-4662-8f0d-ab77455f2538
Macklon, N.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Cheong, Y.
4efbba2a-3036-4dce-82f1-8b4017952c83

Shreeve, N., Cagampang, F., Sadek, K., Tolhurst, M., Houldey, A., Hill, C. M., Brook, N., Macklon, N. and Cheong, Y. (2013) Poor sleep in PCOS; is melatonin the culprit? Human Reproduction, 28 (5), 1348-1353. (doi:10.1093/humrep/det013). (PMID:23438443)

Record type: Article

Abstract

STUDY QUESTION: Are daily cycles in urinary melatonin and oxidative stress marker levels (8-hydroxydeoxyguanosine) altered in PCOS, and is this associated with changes in sleep quality?

SUMMARY ANSWER: There is an association between elevated nighttime melatonin and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels, and poor sleep quality in our PCOS study group.

WHAT IS KNOWN ALREADY: Women with PCOS are known to have poorer sleep. However, there have been few studies examining the possible association between melatonin levels and sleep quality in women with polycystic ovarian syndrome (PCOS).

STUDY DESIGN, SIZE, DURATION: This is a case-control study of PCOS (n = 26) and non-PCOS control (n = 26) subjects recruited from a tertiary gynaecological centre.

PARTICIPANTS/MATERIALS, SETTING, METHODS: The participants were requested to complete sleep questionnaires for a month. In a subgroup from these cohorts (PCOS, n = 15; controls, n = 18), urine samples were also collected at various time points over a 24-h period. In addition, their sleep patterns and lighting environment were monitored for 3 consecutive days and nights using a wrist-mounted Actiwatch device.

MAIN RESULTS AND THE ROLE OF CHANCE: PCOS women had significantly elevated night-time urinary levels of the melatonin metabolite 6-sulfatoxymelatonin (aMT6s) and of 8-OHdG (both at P < 0.05), as well as significantly reduced sleep quality (P < 0.05), compared with the controls.

LIMITATIONS, REASONS FOR CAUTION: Due to the small sample size of the study, further studies will be required to confirm our findings.

WIDER IMPLICATIONS OF THE FINDINGS: Our preliminary work provides a possible new insight into the interactions between melatonin, increased oxidative stress and sleep in women with PCOS.

Full text not available from this repository.

More information

Published date: May 2013
Keywords: PCOS, melatonin, ovary, sleep, oxidative stress
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 351720
URI: https://eprints.soton.ac.uk/id/eprint/351720
PURE UUID: bcbb45f3-ebbb-4faa-b7bf-dc6d35b4b48b
ORCID for F. Cagampang: ORCID iD orcid.org/0000-0003-4404-9853
ORCID for C. M. Hill: ORCID iD orcid.org/0000-0003-2372-5904
ORCID for Y. Cheong: ORCID iD orcid.org/0000-0001-7687-4597

Catalogue record

Date deposited: 24 Apr 2013 08:43
Last modified: 03 Dec 2019 01:55

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Contributors

Author: N. Shreeve
Author: F. Cagampang ORCID iD
Author: K. Sadek
Author: M. Tolhurst
Author: A. Houldey
Author: C. M. Hill ORCID iD
Author: N. Brook
Author: N. Macklon
Author: Y. Cheong ORCID iD

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