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Maternal cardiovascular risk profile after placental abruption

Maternal cardiovascular risk profile after placental abruption
Maternal cardiovascular risk profile after placental abruption
The prevalence of premature cardiovascular diseases (CVD) is increased in women with a history of maternal placental syndromes, including pregnancy-associated hypertensive disorders (eg, preeclampsia), fetal growth restriction, and placental abruption. Whereas previous studies have shown a high prevalence of CVD risk factors after pregnancies complicated by preeclampsia, this has not been studied for women with a history of placental abruption. To explore the association of placental abruption with CVD risk factors after delivery, we compared 75 women with a history of placental abruption with a control group of 79 women with uneventful pregnancies at 6 to 9 months postpartum for the presence of common CVD risk factors. In a subanalysis, data were stratified according to the presence or absence of concomitant hypertensive disease and further adjusted for potential confounders. Women with previous placental abruption had significantly higher mean systolic blood pressure, body-mass index, fasting blood glucose, C-reactive protein, total cholesterol, high-density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol as compared with controls with only uneventful pregnancies. In the subanalysis, all differences remained significant for women with a history of placental abruption only (ie, without concomitant gestational hypertension), except for the associations with low-density lipoprotein-cholesterol and diastolic and systolic blood pressure. Most likely, the identified CVD risk factors predispose to placental abruption and development of premature CVD later in life.
cardiovascular risk factors, dyslipidemia, placental abruption, pregnancy, prevention
0194-911X
Veerbeek, Jan H.W.
8e35905c-b7c9-4a45-af5d-c77327344191
Smit, Janine G.
5241ee9b-2547-43df-84fe-290129d755cb
Koster, Maria P.H.
38a1cb79-3b2f-460d-a552-bb8cfecdd0c1
Post Uiterweer, Emiel D.
b1821f77-a80a-4563-b240-bf2f9e308ef0
van Rijn, Bas B.
c958dfb5-2010-46de-a350-4903295ac340
Koenen, Steven V.
22ddfc92-928d-4347-9e31-38cb12f68fdf
Franx, Arie
2376857f-07db-4821-9512-a7b55036b6f0
Veerbeek, Jan H.W.
8e35905c-b7c9-4a45-af5d-c77327344191
Smit, Janine G.
5241ee9b-2547-43df-84fe-290129d755cb
Koster, Maria P.H.
38a1cb79-3b2f-460d-a552-bb8cfecdd0c1
Post Uiterweer, Emiel D.
b1821f77-a80a-4563-b240-bf2f9e308ef0
van Rijn, Bas B.
c958dfb5-2010-46de-a350-4903295ac340
Koenen, Steven V.
22ddfc92-928d-4347-9e31-38cb12f68fdf
Franx, Arie
2376857f-07db-4821-9512-a7b55036b6f0

Veerbeek, Jan H.W., Smit, Janine G., Koster, Maria P.H., Post Uiterweer, Emiel D., van Rijn, Bas B., Koenen, Steven V. and Franx, Arie (2013) Maternal cardiovascular risk profile after placental abruption. Hypertension. (doi:10.1161/hypertensionaha.111.00930). (PMID:23529170)

Record type: Article

Abstract

The prevalence of premature cardiovascular diseases (CVD) is increased in women with a history of maternal placental syndromes, including pregnancy-associated hypertensive disorders (eg, preeclampsia), fetal growth restriction, and placental abruption. Whereas previous studies have shown a high prevalence of CVD risk factors after pregnancies complicated by preeclampsia, this has not been studied for women with a history of placental abruption. To explore the association of placental abruption with CVD risk factors after delivery, we compared 75 women with a history of placental abruption with a control group of 79 women with uneventful pregnancies at 6 to 9 months postpartum for the presence of common CVD risk factors. In a subanalysis, data were stratified according to the presence or absence of concomitant hypertensive disease and further adjusted for potential confounders. Women with previous placental abruption had significantly higher mean systolic blood pressure, body-mass index, fasting blood glucose, C-reactive protein, total cholesterol, high-density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol as compared with controls with only uneventful pregnancies. In the subanalysis, all differences remained significant for women with a history of placental abruption only (ie, without concomitant gestational hypertension), except for the associations with low-density lipoprotein-cholesterol and diastolic and systolic blood pressure. Most likely, the identified CVD risk factors predispose to placental abruption and development of premature CVD later in life.

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More information

Accepted/In Press date: 2013
e-pub ahead of print date: 25 March 2013
Keywords: cardiovascular risk factors, dyslipidemia, placental abruption, pregnancy, prevention
Organisations: Human Development & Health

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Local EPrints ID: 352042
URI: http://eprints.soton.ac.uk/id/eprint/352042
ISSN: 0194-911X
PURE UUID: c72e50f5-9b74-453a-bd33-71c4c310502e

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Date deposited: 01 May 2013 11:46
Last modified: 22 Jul 2022 18:30

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Contributors

Author: Jan H.W. Veerbeek
Author: Janine G. Smit
Author: Maria P.H. Koster
Author: Emiel D. Post Uiterweer
Author: Bas B. van Rijn
Author: Steven V. Koenen
Author: Arie Franx

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