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Cardiovascular disease risk factors in women with a history of early-onset preeclampsia

Cardiovascular disease risk factors in women with a history of early-onset preeclampsia
Cardiovascular disease risk factors in women with a history of early-onset preeclampsia
Objective: to assess the prevalence of established cardiovascular disease risk factors and to estimate 10-year absolute risk of cardiovascular disease after early-onset preeclampsia.

Methods: we assessed major cardiovascular disease risk factors in 243 primiparous women with a history of early-onset preeclampsia (delivery at less than 34 weeks of gestation) at least 6 months after delivery; 374 healthy nonpregnant women of similar age served as a reference group.

Results: after adjustment for age, we observed significantly higher means for body mass index, blood pressure, total and low-density lipoprotein cholesterol, triglycerides, glucose, and lower mean high-density lipoprotein cholesterol (all P<.01) in women with previous early-onset preeclampsia compared with the reference group. Prevalence of the metabolic syndrome was 15.2% compared with 4.3% (P<.001), two or more major cardiovascular disease risk factors were present in 51.0% compared with 26.5%, and three or more risk factors were present in 18.9% compared with 6.4%, respectively. Mean estimated 10-year cardiovascular disease risks by the Framingham Risk Score were 1.08% (95% confidence interval 1.04–1.12) and 1.01% (95% CI 1.00–1.01; P<.001) for the difference.

Conclusionn: women with a history of early-onset preeclampsia have a high prevalence of several major cardiovascular disease risk factors. Although the estimated 10-year cardiovascular disease risk is low (less than 5%) after delivery, cardiovascular disease risk is expected to increase rapidly with increasing age.
0029-7844
1040-1048
van Rijn, Bas B.
c958dfb5-2010-46de-a350-4903295ac340
Nijdam, Marie-Elise
28fc3494-c52e-4df9-aaa1-959654733ce7
Bruinse, Hein W.
9cf35612-505e-4035-a2b8-c63a0ec15421
Roest, Mark
370165b6-0adb-44f8-a502-5b97e89745b5
Uiterwaal, Cuno S.
189a4676-8495-43fe-a0ff-df140f03416f
Grobbee, Diederick E.
a4f40bc1-5b92-4210-ab2d-1f65a43b223b
Bots, Michiel L.
1c573cd6-8751-4e70-bff4-aa8895ba842b
Franx, Arie
2376857f-07db-4821-9512-a7b55036b6f0
van Rijn, Bas B.
c958dfb5-2010-46de-a350-4903295ac340
Nijdam, Marie-Elise
28fc3494-c52e-4df9-aaa1-959654733ce7
Bruinse, Hein W.
9cf35612-505e-4035-a2b8-c63a0ec15421
Roest, Mark
370165b6-0adb-44f8-a502-5b97e89745b5
Uiterwaal, Cuno S.
189a4676-8495-43fe-a0ff-df140f03416f
Grobbee, Diederick E.
a4f40bc1-5b92-4210-ab2d-1f65a43b223b
Bots, Michiel L.
1c573cd6-8751-4e70-bff4-aa8895ba842b
Franx, Arie
2376857f-07db-4821-9512-a7b55036b6f0

van Rijn, Bas B., Nijdam, Marie-Elise, Bruinse, Hein W., Roest, Mark, Uiterwaal, Cuno S., Grobbee, Diederick E., Bots, Michiel L. and Franx, Arie (2013) Cardiovascular disease risk factors in women with a history of early-onset preeclampsia. Obstetrics & Gynecology, 121 (5), 1040-1048. (doi:10.1097/AOG.0b013e31828ea3b5).

Record type: Article

Abstract

Objective: to assess the prevalence of established cardiovascular disease risk factors and to estimate 10-year absolute risk of cardiovascular disease after early-onset preeclampsia.

Methods: we assessed major cardiovascular disease risk factors in 243 primiparous women with a history of early-onset preeclampsia (delivery at less than 34 weeks of gestation) at least 6 months after delivery; 374 healthy nonpregnant women of similar age served as a reference group.

Results: after adjustment for age, we observed significantly higher means for body mass index, blood pressure, total and low-density lipoprotein cholesterol, triglycerides, glucose, and lower mean high-density lipoprotein cholesterol (all P<.01) in women with previous early-onset preeclampsia compared with the reference group. Prevalence of the metabolic syndrome was 15.2% compared with 4.3% (P<.001), two or more major cardiovascular disease risk factors were present in 51.0% compared with 26.5%, and three or more risk factors were present in 18.9% compared with 6.4%, respectively. Mean estimated 10-year cardiovascular disease risks by the Framingham Risk Score were 1.08% (95% confidence interval 1.04–1.12) and 1.01% (95% CI 1.00–1.01; P<.001) for the difference.

Conclusionn: women with a history of early-onset preeclampsia have a high prevalence of several major cardiovascular disease risk factors. Although the estimated 10-year cardiovascular disease risk is low (less than 5%) after delivery, cardiovascular disease risk is expected to increase rapidly with increasing age.

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Published date: May 2013
Organisations: Human Development & Health

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Local EPrints ID: 352061
URI: http://eprints.soton.ac.uk/id/eprint/352061
ISSN: 0029-7844
PURE UUID: 697c0a6e-a262-439f-9b95-dd0e06113abe

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Date deposited: 01 May 2013 14:37
Last modified: 22 Jul 2022 18:30

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Contributors

Author: Bas B. van Rijn
Author: Marie-Elise Nijdam
Author: Hein W. Bruinse
Author: Mark Roest
Author: Cuno S. Uiterwaal
Author: Diederick E. Grobbee
Author: Michiel L. Bots
Author: Arie Franx

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