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The impact of coronary bifurcation stenting strategy on health-related functional status: a quality-of-life analysis from the BBC One (British Bifurcation Coronary; Old, New, and Evolving Strategies) study

The impact of coronary bifurcation stenting strategy on health-related functional status: a quality-of-life analysis from the BBC One (British Bifurcation Coronary; Old, New, and Evolving Strategies) study
The impact of coronary bifurcation stenting strategy on health-related functional status: a quality-of-life analysis from the BBC One (British Bifurcation Coronary; Old, New, and Evolving Strategies) study
Objectives
This study sought to assess the impact of coronary bifurcation stenting on health-related functional status, using the Seattle Angina Questionnaire (SAQ), for participants in the BBC ONE (British Bifurcation Coronary; Old, New, and Evolving Strategies) trial and to compare simple versus complex bifurcation stenting strategies in this regard.

Background
Large randomized studies have examined outcomes from bifurcation stenting with drug-eluting stents. They have reported on major adverse cardiovascular events and angiographic follow-up. However, a principal goal of percutaneous coronary intervention is symptom control and improvement in quality of life, yet there are no published data from these trials on this aspect. Furthermore, it is unknown whether simple versus complex stenting strategies have different effects on angina control and quality of life.

Methods
The BBC ONE study randomized 500 subjects to bifurcation stenting using either a simple (provisional T) or complex (crush or culotte) approach. Subjects completed the SAQ at baseline and at 9 months after percutaneous coronary intervention. Canadian Cardiovascular Society class and antianginal drug use were also evaluated.

Results
Bifurcation stenting was associated with significant improvements on SAQ scales and in Canadian Cardiovascular Society class (baseline: 5.3% subjects were class 0; follow-up: 64.0% were class 0; p < 0.001) and a significant reduction in the number of antianginal drugs used (median decrease: 1; p < 0.001). Simple and complex strategies did not differ significantly for changes in the SAQ, actual SAQ scores, or use of antianginal drugs.

Conclusions
Regardless of chosen strategy, bifurcation stenting produced significant functional improvements in angina-rel
1936-8798
139-145
Sirker, A.
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Sohal, M.
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Oldroyd, K.
d24e546a-5a98-496a-8267-c86c5974a710
Curzen, N.
70f3ea49-51b1-418f-8e56-8210aef1abf4
Stables, R.
6aaefe18-cce7-42a8-a160-5bcd8763554b
De Belder, A.
e807fdba-2146-4503-a70a-e77597af4f3b
Hildick-Smith, D.
511ddc70-0414-40bb-9487-028bd90cf23d
Sirker, A.
fef98861-3178-4658-82cc-0648b8e6a874
Sohal, M.
766a340d-7266-420b-ae0e-f9128f5eee5c
Oldroyd, K.
d24e546a-5a98-496a-8267-c86c5974a710
Curzen, N.
70f3ea49-51b1-418f-8e56-8210aef1abf4
Stables, R.
6aaefe18-cce7-42a8-a160-5bcd8763554b
De Belder, A.
e807fdba-2146-4503-a70a-e77597af4f3b
Hildick-Smith, D.
511ddc70-0414-40bb-9487-028bd90cf23d

Sirker, A., Sohal, M., Oldroyd, K., Curzen, N., Stables, R., De Belder, A. and Hildick-Smith, D. (2013) The impact of coronary bifurcation stenting strategy on health-related functional status: a quality-of-life analysis from the BBC One (British Bifurcation Coronary; Old, New, and Evolving Strategies) study. JACC Cardiovascular Interventions, 6, 139-145. (doi:10.1016/j.jcin.2012.10.010).

Record type: Article

Abstract

Objectives
This study sought to assess the impact of coronary bifurcation stenting on health-related functional status, using the Seattle Angina Questionnaire (SAQ), for participants in the BBC ONE (British Bifurcation Coronary; Old, New, and Evolving Strategies) trial and to compare simple versus complex bifurcation stenting strategies in this regard.

Background
Large randomized studies have examined outcomes from bifurcation stenting with drug-eluting stents. They have reported on major adverse cardiovascular events and angiographic follow-up. However, a principal goal of percutaneous coronary intervention is symptom control and improvement in quality of life, yet there are no published data from these trials on this aspect. Furthermore, it is unknown whether simple versus complex stenting strategies have different effects on angina control and quality of life.

Methods
The BBC ONE study randomized 500 subjects to bifurcation stenting using either a simple (provisional T) or complex (crush or culotte) approach. Subjects completed the SAQ at baseline and at 9 months after percutaneous coronary intervention. Canadian Cardiovascular Society class and antianginal drug use were also evaluated.

Results
Bifurcation stenting was associated with significant improvements on SAQ scales and in Canadian Cardiovascular Society class (baseline: 5.3% subjects were class 0; follow-up: 64.0% were class 0; p < 0.001) and a significant reduction in the number of antianginal drugs used (median decrease: 1; p < 0.001). Simple and complex strategies did not differ significantly for changes in the SAQ, actual SAQ scores, or use of antianginal drugs.

Conclusions
Regardless of chosen strategy, bifurcation stenting produced significant functional improvements in angina-rel

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More information

Published date: February 2013
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 352070
URI: http://eprints.soton.ac.uk/id/eprint/352070
ISSN: 1936-8798
PURE UUID: d0cdbd0a-8ad1-47b8-b7b8-de61700934d1
ORCID for N. Curzen: ORCID iD orcid.org/0000-0001-9651-7829

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Date deposited: 07 May 2013 09:30
Last modified: 09 Jan 2022 03:19

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Contributors

Author: A. Sirker
Author: M. Sohal
Author: K. Oldroyd
Author: N. Curzen ORCID iD
Author: R. Stables
Author: A. De Belder
Author: D. Hildick-Smith

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