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Long-term statin administration to dams on high-fat diet protects not only them but also their offspring from cardiovascular risk

Long-term statin administration to dams on high-fat diet protects not only them but also their offspring from cardiovascular risk
Long-term statin administration to dams on high-fat diet protects not only them but also their offspring from cardiovascular risk
We aimed to study the effects of long-term statin administration to high fat (HF)-fed female mice from the time they were weaned through to pregnancy and lactation on cardiovascular and metabolic risk factors in their HF-fed offspring. Female C57 mice on HF (45% kcal fat) were given pravastatin in their drinking water from the time they were weaned, during pregnancy and lactation. Weaned offspring were then fed an HF diet until adulthood generating the dam/offspring dietary groups HF/HF and HF plus pravastatin from the time dams were weaned, during pregnancy and lactation/HF (HF+S/HF). These groups were compared with offspring from mothers fed standard chow (control) which were then fed a control diet up to adulthood (control/control; C/C). HF+S dams showed significantly reduced total cholesterol concentrations and systolic blood pressure (SBP) versus HF dams. The reduction in total cholesterol and SBP in the HF+S dams did not restore values to those observed in the C group. Both male and female HF+S/HF offspring were significantly lighter in weight, and had lower SBP and serum cholesterol concentrations versus HF/HF. HF/HF offspring had elevated C-reactive protein levels but HF+S/HF animals of both sexes had reduced levels similar to those found in the C/C group. Long-term pravastatin administration to dams not only protects them from the deleterious effects of an HF diet, but this long-term maternal statin protection also has an equal and permanent effect in both male and female offspring up to their adult life, which is a novel finding.
0250-6807
248-254
Elahi, M. M.
4bc1fc90-4bf2-4d9f-bb3d-ade8b53f5c2b
Cagampang, F. R.
7cf57d52-4a65-4554-8306-ed65226bc50e
Ohri, Sunil K.
8aa5698c-78cf-4f59-a5af-5afa46f0348c
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Elahi, M. M.
4bc1fc90-4bf2-4d9f-bb3d-ade8b53f5c2b
Cagampang, F. R.
7cf57d52-4a65-4554-8306-ed65226bc50e
Ohri, Sunil K.
8aa5698c-78cf-4f59-a5af-5afa46f0348c
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f

Elahi, M. M., Cagampang, F. R., Ohri, Sunil K. and Hanson, Mark A. (2013) Long-term statin administration to dams on high-fat diet protects not only them but also their offspring from cardiovascular risk. Annals of Nutrition and Metabolism, 62 (3), 248-254. (doi:10.1159/000346037). (PMID:23594919)

Record type: Article

Abstract

We aimed to study the effects of long-term statin administration to high fat (HF)-fed female mice from the time they were weaned through to pregnancy and lactation on cardiovascular and metabolic risk factors in their HF-fed offspring. Female C57 mice on HF (45% kcal fat) were given pravastatin in their drinking water from the time they were weaned, during pregnancy and lactation. Weaned offspring were then fed an HF diet until adulthood generating the dam/offspring dietary groups HF/HF and HF plus pravastatin from the time dams were weaned, during pregnancy and lactation/HF (HF+S/HF). These groups were compared with offspring from mothers fed standard chow (control) which were then fed a control diet up to adulthood (control/control; C/C). HF+S dams showed significantly reduced total cholesterol concentrations and systolic blood pressure (SBP) versus HF dams. The reduction in total cholesterol and SBP in the HF+S dams did not restore values to those observed in the C group. Both male and female HF+S/HF offspring were significantly lighter in weight, and had lower SBP and serum cholesterol concentrations versus HF/HF. HF/HF offspring had elevated C-reactive protein levels but HF+S/HF animals of both sexes had reduced levels similar to those found in the C/C group. Long-term pravastatin administration to dams not only protects them from the deleterious effects of an HF diet, but this long-term maternal statin protection also has an equal and permanent effect in both male and female offspring up to their adult life, which is a novel finding.

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e-pub ahead of print date: 16 April 2013
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 352151
URI: http://eprints.soton.ac.uk/id/eprint/352151
ISSN: 0250-6807
PURE UUID: d7c266c9-a980-46ef-a373-4bcdcf4b334c
ORCID for F. R. Cagampang: ORCID iD orcid.org/0000-0003-4404-9853
ORCID for Mark A. Hanson: ORCID iD orcid.org/0000-0002-6907-613X

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Date deposited: 03 May 2013 14:54
Last modified: 08 Jan 2022 02:57

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Contributors

Author: M. M. Elahi
Author: F. R. Cagampang ORCID iD
Author: Sunil K. Ohri
Author: Mark A. Hanson ORCID iD

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