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A sense of place: a model of synaptic plasticity in the hippocampus

A sense of place: a model of synaptic plasticity in the hippocampus
A sense of place: a model of synaptic plasticity in the hippocampus
Artificial synaptic plasticity is a programming approach used in artificial neural simulations to replicate the change in efficacy between two synapses observed in biological neurons. This biological synaptic plasticity is thought to enable neurons to control the connections between them. This control is then thought to lead to complex behaviour such as path integration. This stochastic process of activity dependent biological synaptic plasticity forces groups of neurons to operate together. The operation of large subsets of neurons underlies the cognition and memory formation in animals, without which life could not flourish.

The most well studied region in the brain for synaptic plasticity is the hippocampus.This region was the first to display both long term potentiation, as well as long term depression. It has also been implicated in memory retention and has been shown to display spatial tuning. Furthermore, the discovery of place cells, and the more recent discovery of grid cells has created a surge of interest in the region. Entirely plausible models for grid field, place field, and memory formation have been suggested. The hippocampus could very well be the first brain region to be understood which does not represent purely sensory input.

This thesis applies the rules of activity dependent synaptic plasticity to the hippocampus by modelling the region in silicon. This model focuses on the head direction cells, grid cells, and place cells. The head direction cells are generated using rotational inputs. The grid cells are then generated using both head direction input and forward motion inputs. Finally, the place cells are created using grid cell inputs. To facilitate the construction of this model, a simulator has also been created.
Askari, Peyman
3aa6c544-9c91-470a-9a8c-37486cd44177
Askari, Peyman
3aa6c544-9c91-470a-9a8c-37486cd44177
Shadbolt, Nigel
5c5acdf4-ad42-49b6-81fe-e9db58c2caf7

Askari, Peyman (2013) A sense of place: a model of synaptic plasticity in the hippocampus. University of Southampton, Faculty of Physical Sciences & Engineering, Doctoral Thesis, 229pp.

Record type: Thesis (Doctoral)

Abstract

Artificial synaptic plasticity is a programming approach used in artificial neural simulations to replicate the change in efficacy between two synapses observed in biological neurons. This biological synaptic plasticity is thought to enable neurons to control the connections between them. This control is then thought to lead to complex behaviour such as path integration. This stochastic process of activity dependent biological synaptic plasticity forces groups of neurons to operate together. The operation of large subsets of neurons underlies the cognition and memory formation in animals, without which life could not flourish.

The most well studied region in the brain for synaptic plasticity is the hippocampus.This region was the first to display both long term potentiation, as well as long term depression. It has also been implicated in memory retention and has been shown to display spatial tuning. Furthermore, the discovery of place cells, and the more recent discovery of grid cells has created a surge of interest in the region. Entirely plausible models for grid field, place field, and memory formation have been suggested. The hippocampus could very well be the first brain region to be understood which does not represent purely sensory input.

This thesis applies the rules of activity dependent synaptic plasticity to the hippocampus by modelling the region in silicon. This model focuses on the head direction cells, grid cells, and place cells. The head direction cells are generated using rotational inputs. The grid cells are then generated using both head direction input and forward motion inputs. Finally, the place cells are created using grid cell inputs. To facilitate the construction of this model, a simulator has also been created.

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Published date: February 2013
Organisations: University of Southampton, Web & Internet Science

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Local EPrints ID: 352322
URI: http://eprints.soton.ac.uk/id/eprint/352322
PURE UUID: b9d172e8-62ec-46ce-867d-55241f334e18

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Date deposited: 09 May 2013 11:52
Last modified: 18 Jul 2017 04:15

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